Enantioselective Total Synthesis of (+)-Neostenine

A chirality transfer approach using acyclic polyol intermediates for the synthesis of (+)‐neostenine (1) has been developed. The sequential Overman/Claisen rearrangement of an allylic 1,2‐diol was especially useful, installing two contiguous stereocenters with complete diastereoselectivity in a one‐...

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Veröffentlicht in:	Chemistry : a European journal 2016-03, Vol.22 (10), p.3300-3303
Hauptverfasser:	Nakayama, Yasuaki, Maeda, Yuichiro, Kotatsu, Masayuki, Sekiya, Ruriko, Ichiki, Masato, Sato, Takaaki, Chida, Noritaka
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloid Alkaloids allylic compound Amides Bonding Chemistry Chirality diol Enantiomers Intermediates Polyols Reduction sigmatropic rearrangement Synthesis total synthesis
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