Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1- 13 C]pyruvate and 13 C-urea
To demonstrate the feasibility of imaging a bolus of co-polarized [1- C]pyruvate and C-urea to simultaneously assess both metabolism and perfusion in the rodent heart. Copolarized [1- C]pyruvate and C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanne...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-01, Vol.77 (1), p.151-158 |
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| container_title | Magnetic resonance in medicine |
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| creator | Lau, Angus Z Miller, Jack J Robson, Matthew D Tyler, Damian J |
| description | To demonstrate the feasibility of imaging a bolus of co-polarized [1-
C]pyruvate and
C-urea to simultaneously assess both metabolism and perfusion in the rodent heart.
Copolarized [1-
C]pyruvate and
C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanned in a two-factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress-induced hyperemia).
Alterations in metabolism were detected by changes in pyruvate metabolism into
C-bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals.
The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized
C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151-158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. |
| doi_str_mv | 10.1002/mrm.26106 |
| format | Article |
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C]pyruvate and
C-urea to simultaneously assess both metabolism and perfusion in the rodent heart.
Copolarized [1-
C]pyruvate and
C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanned in a two-factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress-induced hyperemia).
Alterations in metabolism were detected by changes in pyruvate metabolism into
C-bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals.
The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized
C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151-158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26106</identifier><identifier>PMID: 26743440</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Carbon Isotopes - metabolism ; Heart - diagnostic imaging ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging - methods ; Male ; Myocardium - metabolism ; Perfusion Imaging - methods ; Pyruvic Acid - metabolism ; Rats ; Rats, Wistar ; Urea - metabolism</subject><ispartof>Magnetic resonance in medicine, 2017-01, Vol.77 (1), p.151-158</ispartof><rights>2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1300-50d435fdcbe7ff868cf37d5f1ee8c175fe882ddc1630697f53860f12aa2569e83</citedby><cites>FETCH-LOGICAL-c1300-50d435fdcbe7ff868cf37d5f1ee8c175fe882ddc1630697f53860f12aa2569e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26743440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, Angus Z</creatorcontrib><creatorcontrib>Miller, Jack J</creatorcontrib><creatorcontrib>Robson, Matthew D</creatorcontrib><creatorcontrib>Tyler, Damian J</creatorcontrib><title>Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1- 13 C]pyruvate and 13 C-urea</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>To demonstrate the feasibility of imaging a bolus of co-polarized [1-
C]pyruvate and
C-urea to simultaneously assess both metabolism and perfusion in the rodent heart.
Copolarized [1-
C]pyruvate and
C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanned in a two-factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress-induced hyperemia).
Alterations in metabolism were detected by changes in pyruvate metabolism into
C-bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals.
The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized
C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151-158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.</description><subject>Animals</subject><subject>Carbon Isotopes - metabolism</subject><subject>Heart - diagnostic imaging</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Myocardium - metabolism</subject><subject>Perfusion Imaging - methods</subject><subject>Pyruvic Acid - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urea - metabolism</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKxDAUhoMozji68AUkS110zL3pUgZvMOBCXYmUTHIilaatSSuMT2_noptz4PD9P5wPoXNK5pQQdh1imDNFiTpAUyoZy5gsxCGaklyQjNNCTNBJSp-EkKLIxTGaMJULLgSZovBchaHuTQPtkLBJCVIK0PS49dia6CpjcYDerNq6SgGbxuEOoh9S1TZ4nM0Htm3X1iZWP-DwG80w5Xjx3q3j8G162CY2l2yIYE7RkTd1grP9nqHXu9uXxUO2fLp_XNwsM0s5IZkkTnDpnV1B7r1W2nqeO-kpgLY0lx60Zs5ZqjhRRe4l14p4yoxhUhWg-Qxd7nq72H4NkPoyVMlCXe_-LKlmSgkhRwszdLVDbWxTiuDLLlbBxHVJSbmxW452y63dkb3Y1w6rAO6f_NPJfwFbm3U_</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Lau, Angus Z</creator><creator>Miller, Jack J</creator><creator>Robson, Matthew D</creator><creator>Tyler, Damian J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1- 13 C]pyruvate and 13 C-urea</title><author>Lau, Angus Z ; Miller, Jack J ; Robson, Matthew D ; Tyler, Damian J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1300-50d435fdcbe7ff868cf37d5f1ee8c175fe882ddc1630697f53860f12aa2569e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Carbon Isotopes - metabolism</topic><topic>Heart - diagnostic imaging</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Myocardium - metabolism</topic><topic>Perfusion Imaging - methods</topic><topic>Pyruvic Acid - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Urea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, Angus Z</creatorcontrib><creatorcontrib>Miller, Jack J</creatorcontrib><creatorcontrib>Robson, Matthew D</creatorcontrib><creatorcontrib>Tyler, Damian J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, Angus Z</au><au>Miller, Jack J</au><au>Robson, Matthew D</au><au>Tyler, Damian J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1- 13 C]pyruvate and 13 C-urea</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2017-01</date><risdate>2017</risdate><volume>77</volume><issue>1</issue><spage>151</spage><epage>158</epage><pages>151-158</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>To demonstrate the feasibility of imaging a bolus of co-polarized [1-
C]pyruvate and
C-urea to simultaneously assess both metabolism and perfusion in the rodent heart.
Copolarized [1-
C]pyruvate and
C-urea was imaged using a multi-echo, flow-sensitized spiral pulse sequence. Healthy rats were scanned in a two-factor factorial design (n = 12 total; metabolism: overnight fasting versus fed with dichloroacetate injection; perfusion: rest versus adenosine stress-induced hyperemia).
Alterations in metabolism were detected by changes in pyruvate metabolism into
C-bicarbonate. Statistically independent alterations in perfusion were detected by changes in myocardial pyruvate and urea signals.
The new pulse sequence was used to obtain maps of metabolism and perfusion in the rodent heart in a single acquisition. This hyperpolarized
C imaging test is expected to enable new studies in which the cardiac metabolism/perfusion mismatch can be studied in the acute environment. Magn Reson Med 77:151-158, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.</abstract><cop>United States</cop><pmid>26743440</pmid><doi>10.1002/mrm.26106</doi><tpages>8</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2017-01, Vol.77 (1), p.151-158 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Animals Carbon Isotopes - metabolism Heart - diagnostic imaging Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Male Myocardium - metabolism Perfusion Imaging - methods Pyruvic Acid - metabolism Rats Rats, Wistar Urea - metabolism |
| title | Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1- 13 C]pyruvate and 13 C-urea |
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