Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children With Mild to Moderate Sepsis
Objective: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Methods: The study was a prospective randomized, double-blind, placebo-...
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| Veröffentlicht in: | Journal of intensive care medicine 2017-03, Vol.32 (3), p.212-217 |
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| container_title | Journal of intensive care medicine |
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| creator | Al-Biltagi, Mohammed Abdul Moety Abo-Elezz, Ahmed Abd ElBasset Abd-Elhafez, Maher Ahmed Mabrouk, Maaly Mohamed Suliman, Ghada Abudelmomen |
| description | Objective:
The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level.
Methods:
The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation.
Results:
There was a significant improvement in hemoglobin percentage (P < .0001), total white blood cell (WBC) count (P < .0001), and platelet count (P < .0001) and significant decrease in CRP (P < .0001), ESR (P < .0001), IL-6 (P < .0001), and albumin level (P < .001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P < .01) and decreased death rate than the nonsupplemented group.
Conclusion:
Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids. |
| doi_str_mv | 10.1177/0885066615623927 |
| format | Article |
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The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level.
Methods:
The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation.
Results:
There was a significant improvement in hemoglobin percentage (P < .0001), total white blood cell (WBC) count (P < .0001), and platelet count (P < .0001) and significant decrease in CRP (P < .0001), ESR (P < .0001), IL-6 (P < .0001), and albumin level (P < .001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P < .01) and decreased death rate than the nonsupplemented group.
Conclusion:
Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids.]]></description><identifier>ISSN: 0885-0666</identifier><identifier>EISSN: 1525-1489</identifier><identifier>DOI: 10.1177/0885066615623927</identifier><identifier>PMID: 26704762</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>C-Reactive Protein ; Child, Preschool ; Critical Care ; Double-Blind Method ; Enteral Nutrition - methods ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Humans ; Intensive Care Units, Pediatric ; Interleukin-6 ; Lymphocyte Activation ; Lymphocyte Count ; Male ; Prospective Studies ; Sepsis - diet therapy ; Sepsis - immunology ; Treatment Outcome</subject><ispartof>Journal of intensive care medicine, 2017-03, Vol.32 (3), p.212-217</ispartof><rights>The Author(s) 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-747b9c5985f1145b89c0be76c74497cbefc700a41ec5d2c8f3086cc0baa0b8f73</citedby><cites>FETCH-LOGICAL-c337t-747b9c5985f1145b89c0be76c74497cbefc700a41ec5d2c8f3086cc0baa0b8f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0885066615623927$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0885066615623927$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26704762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Biltagi, Mohammed Abdul Moety</creatorcontrib><creatorcontrib>Abo-Elezz, Ahmed Abd ElBasset</creatorcontrib><creatorcontrib>Abd-Elhafez, Maher Ahmed</creatorcontrib><creatorcontrib>Mabrouk, Maaly Mohamed</creatorcontrib><creatorcontrib>Suliman, Ghada Abudelmomen</creatorcontrib><title>Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children With Mild to Moderate Sepsis</title><title>Journal of intensive care medicine</title><addtitle>J Intensive Care Med</addtitle><description><![CDATA[Objective:
The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level.
Methods:
The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation.
Results:
There was a significant improvement in hemoglobin percentage (P < .0001), total white blood cell (WBC) count (P < .0001), and platelet count (P < .0001) and significant decrease in CRP (P < .0001), ESR (P < .0001), IL-6 (P < .0001), and albumin level (P < .001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P < .01) and decreased death rate than the nonsupplemented group.
Conclusion:
Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids.]]></description><subject>C-Reactive Protein</subject><subject>Child, Preschool</subject><subject>Critical Care</subject><subject>Double-Blind Method</subject><subject>Enteral Nutrition - methods</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive Care Units, Pediatric</subject><subject>Interleukin-6</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Sepsis - diet therapy</subject><subject>Sepsis - immunology</subject><subject>Treatment Outcome</subject><issn>0885-0666</issn><issn>1525-1489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10DtPwzAUBWALgWgp7EzII0vAj8R2RqhaQGrVoSDGyHGuW1d5ETsD_55EBQYkJuvqfvdIPghdU3JHqZT3RKmECCFoIhhPmTxBU5qwJKKxSk_RdFxH436CLrw_EEI54_QcTZiQJJaCTdH-EWqwzjhd4oW1YILHjcWbCnY64njbt20JFdQBhwaHPeBFHaAb8BKgcPUOuxrP964sOqjxuwt7vB6GEa-bYoAB8BZa7_wlOrO69HD1_c7Q23LxOn-OVpunl_nDKjKcyxDJWOapSVKVWErjJFepITlIYWQcp9LkYI0kRMcUTFIwoywnSpjBaE1yZSWfodtjbts1Hz34kFXOGyhLXUPT-4wqJkTMUsYHSo7UdI33Hdis7Vylu8-MkmzsN_vb73By853e5xUUvwc_hQ4gOgKvd5Admr6rh9_-H_gFVD-Bvw</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Al-Biltagi, Mohammed Abdul Moety</creator><creator>Abo-Elezz, Ahmed Abd ElBasset</creator><creator>Abd-Elhafez, Maher Ahmed</creator><creator>Mabrouk, Maaly Mohamed</creator><creator>Suliman, Ghada Abudelmomen</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children With Mild to Moderate Sepsis</title><author>Al-Biltagi, Mohammed Abdul Moety ; Abo-Elezz, Ahmed Abd ElBasset ; Abd-Elhafez, Maher Ahmed ; Mabrouk, Maaly Mohamed ; Suliman, Ghada Abudelmomen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-747b9c5985f1145b89c0be76c74497cbefc700a41ec5d2c8f3086cc0baa0b8f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>C-Reactive Protein</topic><topic>Child, Preschool</topic><topic>Critical Care</topic><topic>Double-Blind Method</topic><topic>Enteral Nutrition - methods</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive Care Units, Pediatric</topic><topic>Interleukin-6</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Sepsis - diet therapy</topic><topic>Sepsis - immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Biltagi, Mohammed Abdul Moety</creatorcontrib><creatorcontrib>Abo-Elezz, Ahmed Abd ElBasset</creatorcontrib><creatorcontrib>Abd-Elhafez, Maher Ahmed</creatorcontrib><creatorcontrib>Mabrouk, Maaly Mohamed</creatorcontrib><creatorcontrib>Suliman, Ghada Abudelmomen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Biltagi, Mohammed Abdul Moety</au><au>Abo-Elezz, Ahmed Abd ElBasset</au><au>Abd-Elhafez, Maher Ahmed</au><au>Mabrouk, Maaly Mohamed</au><au>Suliman, Ghada Abudelmomen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children With Mild to Moderate Sepsis</atitle><jtitle>Journal of intensive care medicine</jtitle><addtitle>J Intensive Care Med</addtitle><date>2017-03</date><risdate>2017</risdate><volume>32</volume><issue>3</issue><spage>212</spage><epage>217</epage><pages>212-217</pages><issn>0885-0666</issn><eissn>1525-1489</eissn><abstract><![CDATA[Objective:
The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level.
Methods:
The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation.
Results:
There was a significant improvement in hemoglobin percentage (P < .0001), total white blood cell (WBC) count (P < .0001), and platelet count (P < .0001) and significant decrease in CRP (P < .0001), ESR (P < .0001), IL-6 (P < .0001), and albumin level (P < .001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P < .01) and decreased death rate than the nonsupplemented group.
Conclusion:
Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids.]]></abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>26704762</pmid><doi>10.1177/0885066615623927</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of intensive care medicine, 2017-03, Vol.32 (3), p.212-217 |
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| source | SAGE Complete A-Z List; MEDLINE |
| subjects | C-Reactive Protein Child, Preschool Critical Care Double-Blind Method Enteral Nutrition - methods Fatty Acids, Omega-3 - therapeutic use Female Humans Intensive Care Units, Pediatric Interleukin-6 Lymphocyte Activation Lymphocyte Count Male Prospective Studies Sepsis - diet therapy Sepsis - immunology Treatment Outcome |
| title | Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children With Mild to Moderate Sepsis |
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