Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)

Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)

Summary Objective Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. Design A po...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical endocrinology (Oxford) 2016-02, Vol.84 (2), p.185-193
Hauptverfasser: Ahn, Seong Hee, Kim, Hyeonmok, Kim, Beom-Jun, Lee, Seung Hun, Koh, Jung-Min
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 193
container_issue 2
container_start_page 185
container_title Clinical endocrinology (Oxford)
container_volume 84
creator Ahn, Seong Hee
Kim, Hyeonmok
Kim, Beom-Jun
Lee, Seung Hun
Koh, Jung-Min
description Summary Objective Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. Design A population‐based, cross‐sectional study from the Korea National Health and Nutrition Examination Survey Participants About 1243 men and 1433 women Measurements Insulin resistance was evaluated using the homoeostasis model assessment‐estimated insulin resistance (HOMA‐IR) index. Femoral neck width and axis length were measured from hip dual‐energy X‐ray absorptiometry scans and combined with BMD, weight and height to calculate composite indices of femoral neck strength relative to load: compression (CSI), bending (BSI) and impact strength indices (ISI). Results HOMA‐IR showed an inverse relationship with CSI, BSI and ISI in both genders before and after adjusting for confounders (P < 0·001–0·029). CSI was more strongly associated with HOMA‐IR than BSI and/or ISI in both genders (P < 0·001–0·013). When men were stratified according to HOMA‐IR quartiles, all strength indices decreased as the quartile increased, after adjusting for all potential confounders (P for trend
doi_str_mv 10.1111/cen.12958
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1826641870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1780515747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4248-a6928f8c478751c9a331d93bbbec0f58f93ad075138979998f15e555516cce2e3</originalsourceid><addsrcrecordid>eNqFkc1uEzEUhUcIRENhwQsgS2zaxbT-GY897KIoTUKjAakFlpbj3KFuZ-xgz0DzLH3ZOk3bBRLibixdf-fo6pwse0_wCUlzasCdEFpx-SIbEVbynNKSv8xGmGGc47IsDrI3MV5jjLnE4nV2QMuClpLgUXa3cHForUMBoo29dgaQdmtkfLfx0faArFtbAxH5BjXQ-aBb5MDcoNgHcD_7qwSgcbTaxU-ovwLU-CGk7bkPoFGte-tdksxBt2m7s66HPtjdGk1vdWfdA4IuhvAbtujovJ6P6-kFWnw_fpu9anQb4d3je5h9O5teTub58stsMRkvc1PQQua6rKhspCmEFJyYSjNG1hVbrVZgcMNlUzG9xumLyUpUVSUbwoGnIaUxQIEdZkd7303wvwaIvepsNNC22oEfoiKSpgyJFPj_qJCYEy4KkdCPf6HXKZmUxY7i6daKYZqo4z1lgo8xQKM2wXY6bBXBaleuSuWqh3IT--HRcVh1sH4mn9pMwOke-GNb2P7bSU2m9ZNlvlek7uH2WaHDjSoFE1z9qGdqiT8vzy6_zpRk92D2vGs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1757879302</pqid></control><display><type>article</type><title>Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)</title><source>Wiley Online Library All Journals</source><creator>Ahn, Seong Hee ; Kim, Hyeonmok ; Kim, Beom-Jun ; Lee, Seung Hun ; Koh, Jung-Min</creator><creatorcontrib>Ahn, Seong Hee ; Kim, Hyeonmok ; Kim, Beom-Jun ; Lee, Seung Hun ; Koh, Jung-Min</creatorcontrib><description>Summary Objective Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. Design A population‐based, cross‐sectional study from the Korea National Health and Nutrition Examination Survey Participants About 1243 men and 1433 women Measurements Insulin resistance was evaluated using the homoeostasis model assessment‐estimated insulin resistance (HOMA‐IR) index. Femoral neck width and axis length were measured from hip dual‐energy X‐ray absorptiometry scans and combined with BMD, weight and height to calculate composite indices of femoral neck strength relative to load: compression (CSI), bending (BSI) and impact strength indices (ISI). Results HOMA‐IR showed an inverse relationship with CSI, BSI and ISI in both genders before and after adjusting for confounders (P &lt; 0·001–0·029). CSI was more strongly associated with HOMA‐IR than BSI and/or ISI in both genders (P &lt; 0·001–0·013). When men were stratified according to HOMA‐IR quartiles, all strength indices decreased as the quartile increased, after adjusting for all potential confounders (P for trend &lt;0·001–0·001), whereas CSI and ISI did in women (P for trend = 0·012 and 0·002, respectively). Fasting insulin levels, but not glucose levels, were negatively associated with all strength indices regardless of confounders (P &lt; 0·001–0·044). Conclusions Insulin resistance is associated with low femoral neck strength, particularly against the compressive load. These findings suggest a better approach to evaluate bone health in insulin‐resistant individuals.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12958</identifier><identifier>PMID: 26426810</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><ispartof>Clinical endocrinology (Oxford), 2016-02, Vol.84 (2), p.185-193</ispartof><rights>2015 John Wiley &amp; Sons Ltd</rights><rights>2015 John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2016 John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4248-a6928f8c478751c9a331d93bbbec0f58f93ad075138979998f15e555516cce2e3</citedby><cites>FETCH-LOGICAL-c4248-a6928f8c478751c9a331d93bbbec0f58f93ad075138979998f15e555516cce2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12958$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12958$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26426810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Seong Hee</creatorcontrib><creatorcontrib>Kim, Hyeonmok</creatorcontrib><creatorcontrib>Kim, Beom-Jun</creatorcontrib><creatorcontrib>Lee, Seung Hun</creatorcontrib><creatorcontrib>Koh, Jung-Min</creatorcontrib><title>Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary Objective Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. Design A population‐based, cross‐sectional study from the Korea National Health and Nutrition Examination Survey Participants About 1243 men and 1433 women Measurements Insulin resistance was evaluated using the homoeostasis model assessment‐estimated insulin resistance (HOMA‐IR) index. Femoral neck width and axis length were measured from hip dual‐energy X‐ray absorptiometry scans and combined with BMD, weight and height to calculate composite indices of femoral neck strength relative to load: compression (CSI), bending (BSI) and impact strength indices (ISI). Results HOMA‐IR showed an inverse relationship with CSI, BSI and ISI in both genders before and after adjusting for confounders (P &lt; 0·001–0·029). CSI was more strongly associated with HOMA‐IR than BSI and/or ISI in both genders (P &lt; 0·001–0·013). When men were stratified according to HOMA‐IR quartiles, all strength indices decreased as the quartile increased, after adjusting for all potential confounders (P for trend &lt;0·001–0·001), whereas CSI and ISI did in women (P for trend = 0·012 and 0·002, respectively). Fasting insulin levels, but not glucose levels, were negatively associated with all strength indices regardless of confounders (P &lt; 0·001–0·044). Conclusions Insulin resistance is associated with low femoral neck strength, particularly against the compressive load. These findings suggest a better approach to evaluate bone health in insulin‐resistant individuals.</description><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc1uEzEUhUcIRENhwQsgS2zaxbT-GY897KIoTUKjAakFlpbj3KFuZ-xgz0DzLH3ZOk3bBRLibixdf-fo6pwse0_wCUlzasCdEFpx-SIbEVbynNKSv8xGmGGc47IsDrI3MV5jjLnE4nV2QMuClpLgUXa3cHForUMBoo29dgaQdmtkfLfx0faArFtbAxH5BjXQ-aBb5MDcoNgHcD_7qwSgcbTaxU-ovwLU-CGk7bkPoFGte-tdksxBt2m7s66HPtjdGk1vdWfdA4IuhvAbtujovJ6P6-kFWnw_fpu9anQb4d3je5h9O5teTub58stsMRkvc1PQQua6rKhspCmEFJyYSjNG1hVbrVZgcMNlUzG9xumLyUpUVSUbwoGnIaUxQIEdZkd7303wvwaIvepsNNC22oEfoiKSpgyJFPj_qJCYEy4KkdCPf6HXKZmUxY7i6daKYZqo4z1lgo8xQKM2wXY6bBXBaleuSuWqh3IT--HRcVh1sH4mn9pMwOke-GNb2P7bSU2m9ZNlvlek7uH2WaHDjSoFE1z9qGdqiT8vzy6_zpRk92D2vGs</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Ahn, Seong Hee</creator><creator>Kim, Hyeonmok</creator><creator>Kim, Beom-Jun</creator><creator>Lee, Seung Hun</creator><creator>Koh, Jung-Min</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)</title><author>Ahn, Seong Hee ; Kim, Hyeonmok ; Kim, Beom-Jun ; Lee, Seung Hun ; Koh, Jung-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4248-a6928f8c478751c9a331d93bbbec0f58f93ad075138979998f15e555516cce2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Seong Hee</creatorcontrib><creatorcontrib>Kim, Hyeonmok</creatorcontrib><creatorcontrib>Kim, Beom-Jun</creatorcontrib><creatorcontrib>Lee, Seung Hun</creatorcontrib><creatorcontrib>Koh, Jung-Min</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Seong Hee</au><au>Kim, Hyeonmok</au><au>Kim, Beom-Jun</au><au>Lee, Seung Hun</au><au>Koh, Jung-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-02</date><risdate>2016</risdate><volume>84</volume><issue>2</issue><spage>185</spage><epage>193</epage><pages>185-193</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary Objective Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. Design A population‐based, cross‐sectional study from the Korea National Health and Nutrition Examination Survey Participants About 1243 men and 1433 women Measurements Insulin resistance was evaluated using the homoeostasis model assessment‐estimated insulin resistance (HOMA‐IR) index. Femoral neck width and axis length were measured from hip dual‐energy X‐ray absorptiometry scans and combined with BMD, weight and height to calculate composite indices of femoral neck strength relative to load: compression (CSI), bending (BSI) and impact strength indices (ISI). Results HOMA‐IR showed an inverse relationship with CSI, BSI and ISI in both genders before and after adjusting for confounders (P &lt; 0·001–0·029). CSI was more strongly associated with HOMA‐IR than BSI and/or ISI in both genders (P &lt; 0·001–0·013). When men were stratified according to HOMA‐IR quartiles, all strength indices decreased as the quartile increased, after adjusting for all potential confounders (P for trend &lt;0·001–0·001), whereas CSI and ISI did in women (P for trend = 0·012 and 0·002, respectively). Fasting insulin levels, but not glucose levels, were negatively associated with all strength indices regardless of confounders (P &lt; 0·001–0·044). Conclusions Insulin resistance is associated with low femoral neck strength, particularly against the compressive load. These findings suggest a better approach to evaluate bone health in insulin‐resistant individuals.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26426810</pmid><doi>10.1111/cen.12958</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0300-0664
ispartof Clinical endocrinology (Oxford), 2016-02, Vol.84 (2), p.185-193
issn 0300-0664
1365-2265
language eng
recordid cdi_proquest_miscellaneous_1826641870
source Wiley Online Library All Journals
title Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T20%3A24%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin%20resistance%20and%20composite%20indices%20of%20femoral%20neck%20strength%20in%20Asians:%20the%20fourth%20Korea%20National%20Health%20and%20Nutrition%20Examination%20Survey%20(KNHANES%20IV)&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Ahn,%20Seong%20Hee&rft.date=2016-02&rft.volume=84&rft.issue=2&rft.spage=185&rft.epage=193&rft.pages=185-193&rft.issn=0300-0664&rft.eissn=1365-2265&rft_id=info:doi/10.1111/cen.12958&rft_dat=%3Cproquest_cross%3E1780515747%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1757879302&rft_id=info:pmid/26426810&rfr_iscdi=true