eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress
Summary Heat‐shock proteins including HSP70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is e...
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| Veröffentlicht in: | Clinical physiology and functional imaging 2017-03, Vol.37 (2), p.99-105 |
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| container_title | Clinical physiology and functional imaging |
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| creator | Bittencourt, Aline Porto, Rossana Rosa |
| description | Summary
Heat‐shock proteins including HSP70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both iHSP70 and eHSP70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of HSP70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro‐inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body. |
| doi_str_mv | 10.1111/cpf.12273 |
| format | Article |
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Heat‐shock proteins including HSP70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both iHSP70 and eHSP70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of HSP70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro‐inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12273</identifier><identifier>PMID: 26183945</identifier><identifier>CODEN: CPFICA</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Animals ; cellular stress ; Central Nervous System - metabolism ; Energy Metabolism ; Exercise - physiology ; extracellular HSP70 ; Extracellular Space - metabolism ; HSP70 Heat-Shock Proteins - blood ; HSP70 Heat-Shock Proteins - metabolism ; Humans ; intracellular HSP70 ; Intracellular Space - metabolism ; Liver - metabolism ; Muscle Contraction ; Muscle, Skeletal - metabolism ; physical exercise ; Signal Transduction ; Stress, Physiological ; tissue response ; Up-Regulation</subject><ispartof>Clinical physiology and functional imaging, 2017-03, Vol.37 (2), p.99-105</ispartof><rights>2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd</rights><rights>2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcpf.12273$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcpf.12273$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26183945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bittencourt, Aline</creatorcontrib><creatorcontrib>Porto, Rossana Rosa</creatorcontrib><title>eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>Summary
Heat‐shock proteins including HSP70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both iHSP70 and eHSP70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of HSP70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro‐inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body.</description><subject>Animals</subject><subject>cellular stress</subject><subject>Central Nervous System - metabolism</subject><subject>Energy Metabolism</subject><subject>Exercise - physiology</subject><subject>extracellular HSP70</subject><subject>Extracellular Space - metabolism</subject><subject>HSP70 Heat-Shock Proteins - blood</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Humans</subject><subject>intracellular HSP70</subject><subject>Intracellular Space - metabolism</subject><subject>Liver - metabolism</subject><subject>Muscle Contraction</subject><subject>Muscle, Skeletal - metabolism</subject><subject>physical exercise</subject><subject>Signal Transduction</subject><subject>Stress, Physiological</subject><subject>tissue response</subject><subject>Up-Regulation</subject><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1PwzAMhiMEYuPjwB9Akbhw6ZY0bdJyQxNjSJNAAiRuVZo6W6YuLU3K2L8nDNgBX2zLj19ZfhG6oGREQ4xVq0c0jgU7QEOaiDQiuXg73NecDtCJcytCqGCJOEaDmNOM5Uk6RBuYPT8JMja7hKWtcGU-oFuA9Vj3VnnTWIcbi_0SsFrKuga7gBsMWoPyuNEYPqFTxsFu2RvnesCuBWW0UcZvsbG4A9cGGcC-wc6Hzp2hIy1rB-e_-RS9Tu9eJrNo_nj_MLmdR20schYxJlJachmnVJQyK3mcQZJwIiop0zLPNFARpoKDSrKUCJlrzlgMtExLBhWwU3T9o9t2zXsPzhdr4xTUtbTQ9K6gWcw5y9IkCejVP3TV9J0N1wVKEBb-SPNAXf5SfbmGqmg7s5bdtvh7aQDGP8DG1LDdzykpvr0qglfFzqti8jTdFewLrHWFWA</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Bittencourt, Aline</creator><creator>Porto, Rossana Rosa</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TS</scope><scope>7U5</scope><scope>8FD</scope><scope>K9.</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress</title><author>Bittencourt, Aline ; Porto, Rossana Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2793-33751b6a2517ba8b628e44607daa5b98fe176a276ec48507a9f6332e1b5b3ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>cellular stress</topic><topic>Central Nervous System - metabolism</topic><topic>Energy Metabolism</topic><topic>Exercise - physiology</topic><topic>extracellular HSP70</topic><topic>Extracellular Space - metabolism</topic><topic>HSP70 Heat-Shock Proteins - blood</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Humans</topic><topic>intracellular HSP70</topic><topic>Intracellular Space - metabolism</topic><topic>Liver - metabolism</topic><topic>Muscle Contraction</topic><topic>Muscle, Skeletal - metabolism</topic><topic>physical exercise</topic><topic>Signal Transduction</topic><topic>Stress, Physiological</topic><topic>tissue response</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bittencourt, Aline</creatorcontrib><creatorcontrib>Porto, Rossana Rosa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bittencourt, Aline</au><au>Porto, Rossana Rosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2017-03</date><risdate>2017</risdate><volume>37</volume><issue>2</issue><spage>99</spage><epage>105</epage><pages>99-105</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><coden>CPFICA</coden><abstract>Summary
Heat‐shock proteins including HSP70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of HSP70 (eHSP70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both iHSP70 and eHSP70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of HSP70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro‐inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26183945</pmid><doi>10.1111/cpf.12273</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical physiology and functional imaging, 2017-03, Vol.37 (2), p.99-105 |
| issn | 1475-0961 1475-097X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals cellular stress Central Nervous System - metabolism Energy Metabolism Exercise - physiology extracellular HSP70 Extracellular Space - metabolism HSP70 Heat-Shock Proteins - blood HSP70 Heat-Shock Proteins - metabolism Humans intracellular HSP70 Intracellular Space - metabolism Liver - metabolism Muscle Contraction Muscle, Skeletal - metabolism physical exercise Signal Transduction Stress, Physiological tissue response Up-Regulation |
| title | eHSP70/iHSP70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress |
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