The role of rotational thromboelastometry in assessment of haemostasis during pregnancy in women with factor XI deficiency

Introduction Women with factor XI (FXI) deficiency are at an increased risk of bleeding complications at delivery. Obstetric management is complicated by a lack of correlation between FXI level and bleeding risk. Aim The aims of this study were to assess the difference in rotational thromboelastometry (ROTEM®) in parturient women with FXI deficiency compared to parturient and non‐parturient controls and to evaluate the usefulness of ROTEM® in assessing bleeding risk at delivery in women with FXI deficiency. Methods ROTEM® was performed on 60 women: 27 with FXI deficiency, 20 age‐matched parturient controls and 12 non‐parturient controls. Pregnancy outcomes and haemostatic cover was reviewed in 57 deliveries of women with FXI deficiency. Results Women with FXI deficiency had a longer clotting time (CT) and clot formation time (CFT) (P