The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

Previous work in our laboratories provides preclinical evidence that mixed-action delta/mu receptor glycopeptides have equivalent efficacy for treating pain with reduced side effect profiles compared to widely used mu agonist analgesics such as morphine. This study evaluated the rewarding and reinfo...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-05, Vol.132, p.49-55
Hauptverfasser:	Stevenson, Glenn W., Luginbuhl, Amy, Dunbar, Catherine, LaVigne, Justin, Dutra, Julio, Atherton, Phillip, Bell, Brooke, Cone, Katherine, Giuvelis, Denise, Polt, Robin, Streicher, John M., Bilsky, Edward J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Barrestin2 cAMP Conditioned place preference Delta opioid receptor (DOR) Drug self-administration rats
Online-Zugang:	Volltext
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