Tgf-β1 produced by activated CD4+ T Cells Antagonizes T Cell Surveillance of Tumor Development
TGFβ1 is a regulatory cytokine with a crucial function in the control of T cell tolerance to tumors. Our recent study revealed that T cell-produced TGFβ1 is essential for inhibiting cytotoxic T cell responses to tumors. However, the exact TGFβ1-producing T cell subset required for tumor immune evasi...
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| Veröffentlicht in: | Oncoimmunology 2012-03, Vol.1 (2), p.162-171 |
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| creator | Donkor, Moses K. Sarkar, Abira Li, Ming O. |
| description | TGFβ1 is a regulatory cytokine with a crucial function in the control of T cell tolerance to tumors. Our recent study revealed that T cell-produced TGFβ1 is essential for inhibiting cytotoxic T cell responses to tumors. However, the exact TGFβ1-producing T cell subset required for tumor immune evasion remains unknown. Here we showed that deletion of TGFβ1 from CD8
+
T cells or Foxp3
+
regulatory T (Treg) cells did not protect mice against transplanted tumors. However, absence of TGFβ1 produced by activated CD4
+
T cells and Treg cells inhibited tumor growth, and protected mice from spontaneous prostate cancer. These findings suggest that TGFβ1 produced by activated CD4
+
T cells is a necessary requirement for tumor evasion from immunosurveillance. |
| doi_str_mv | 10.4161/onci.1.2.18481 |
| format | Article |
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+
T cells or Foxp3
+
regulatory T (Treg) cells did not protect mice against transplanted tumors. However, absence of TGFβ1 produced by activated CD4
+
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+
T cells or Foxp3
+
regulatory T (Treg) cells did not protect mice against transplanted tumors. However, absence of TGFβ1 produced by activated CD4
+
T cells and Treg cells inhibited tumor growth, and protected mice from spontaneous prostate cancer. These findings suggest that TGFβ1 produced by activated CD4
+
T cells is a necessary requirement for tumor evasion from immunosurveillance.</description><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cycle</subject><subject>immunosurveillance</subject><subject>immunotherapy</subject><subject>Landes</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Research Paper</subject><subject>T cell tolerance</subject><subject>TGFβ</subject><subject>tumor immunity</subject><issn>2162-4011</issn><issn>2162-402X</issn><issn>2162-402X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><recordid>eNqFUctu1DAUjRCIVqVblshLJJTgR-KMJYRUpVAqtcyCQWJnOc71YOTEwU6mGj6LD-k34WGGARYIb_y455x7rk-WPSW4KAknL_2gbUEKWpBFuSAPslNKOM1LTD89PJ4JOcnOY_yC0-K44kw8zk4orSmmrD7N5Gpt8vvvBI3Bd7OGDrVbpPRkN2pKl-ayfIFWqAHnIroYJrX2g_0G8fCGPsxhA9Y5NWhA3qDV3PuALmEDzo89DNOT7JFRLsL5YT_LPr59s2re5TfLq-vm4ibXZcVJrrXgHIMWCxBMCE2USPZViw3DrTG0ZR2rjWFVhwnnadxU0pVqa1zWLWjNzrLXe91xbnvodGodlJNjsL0KW-mVlX9XBvtZrv1GMlZzIUQSeH4QCP7rDHGSvY0adqOBn6MkC8qrqqoFTtBiD9XBxxjAHNsQLHfByF0wkkgqfwaTCM_-NHeE_4ohAeo9IHXrILbWR20h_elvZU4lTWEu3zfL69vblKWQY2cS89V_mMmLt30_D9759VaqMFnt4OhM7Ol2MD706s4H18lJbZ0PJqRUbZTsH1P9AIi-yDs</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Donkor, Moses K.</creator><creator>Sarkar, Abira</creator><creator>Li, Ming O.</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Tgf-β1 produced by activated CD4+ T Cells Antagonizes T Cell Surveillance of Tumor Development</title><author>Donkor, Moses K. ; Sarkar, Abira ; Li, Ming O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4561-cc9660ec98e9399c1a9162ab0f30bff2b3d37ff35d0166184ab0c5ab7047becc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cycle</topic><topic>immunosurveillance</topic><topic>immunotherapy</topic><topic>Landes</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Research Paper</topic><topic>T cell tolerance</topic><topic>TGFβ</topic><topic>tumor immunity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donkor, Moses K.</creatorcontrib><creatorcontrib>Sarkar, Abira</creatorcontrib><creatorcontrib>Li, Ming O.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncoimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donkor, Moses K.</au><au>Sarkar, Abira</au><au>Li, Ming O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tgf-β1 produced by activated CD4+ T Cells Antagonizes T Cell Surveillance of Tumor Development</atitle><jtitle>Oncoimmunology</jtitle><addtitle>Oncoimmunology</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>1</volume><issue>2</issue><spage>162</spage><epage>171</epage><pages>162-171</pages><issn>2162-4011</issn><issn>2162-402X</issn><eissn>2162-402X</eissn><abstract>TGFβ1 is a regulatory cytokine with a crucial function in the control of T cell tolerance to tumors. Our recent study revealed that T cell-produced TGFβ1 is essential for inhibiting cytotoxic T cell responses to tumors. However, the exact TGFβ1-producing T cell subset required for tumor immune evasion remains unknown. Here we showed that deletion of TGFβ1 from CD8
+
T cells or Foxp3
+
regulatory T (Treg) cells did not protect mice against transplanted tumors. However, absence of TGFβ1 produced by activated CD4
+
T cells and Treg cells inhibited tumor growth, and protected mice from spontaneous prostate cancer. These findings suggest that TGFβ1 produced by activated CD4
+
T cells is a necessary requirement for tumor evasion from immunosurveillance.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>22720237</pmid><doi>10.4161/onci.1.2.18481</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Binding Biology Bioscience Calcium Cancer Cell Cycle immunosurveillance immunotherapy Landes Organogenesis Proteins Research Paper T cell tolerance TGFβ tumor immunity |
| title | Tgf-β1 produced by activated CD4+ T Cells Antagonizes T Cell Surveillance of Tumor Development |
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