TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 super(ARF) and Inhibits Senescence

Prolonged culturing of rodent cells in vitro activates p19 super(ARF) (named p14 super(ARF) in man), resulting in a p53-dependent proliferation arrest known as senescence. The p19 super(ARF)-Mdm2-p53 pathway also serves to protect primary cells against oncogenic transformation. We have used a geneti...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (8), p.6567-6572
Hauptverfasser:	Brummelkamp, T R, Kortlever, R M, Lingbeek, M, Trettel, F, MacDonald, ME, van Lohuizen, M, Bernards, R
Format:	Artikel
Sprache:	eng
Schlagworte:	p14ARF protein p19ARF protein TBX-3 gene ulnar-mammary syndrome
Online-Zugang:	Volltext
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