An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels
Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human t...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-01, Vol.351 (6268), p.77-81 |
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| creator | Haagmans, Bart L. van den Brand, Judith M. A. Raj, V. Stalin Volz, Asisa Wohlsein, Peter Smits, Saskia L. Schipper, Debby Bestebroer, Theo M. Okba, Nisreen Fux, Robert Bensaid, Albert Foz, David Solanes Kuiken, Thijs Baumgärtner, Wolfgang Segalés, Joaquim Sutter, Gerd Osterhaus, Albert D. M. E. |
| description | Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox. |
| doi_str_mv | 10.1126/science.aad1283 |
| format | Article |
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A. ; Raj, V. Stalin ; Volz, Asisa ; Wohlsein, Peter ; Smits, Saskia L. ; Schipper, Debby ; Bestebroer, Theo M. ; Okba, Nisreen ; Fux, Robert ; Bensaid, Albert ; Foz, David Solanes ; Kuiken, Thijs ; Baumgärtner, Wolfgang ; Segalés, Joaquim ; Sutter, Gerd ; Osterhaus, Albert D. M. E.</creator><creatorcontrib>Haagmans, Bart L. ; van den Brand, Judith M. A. ; Raj, V. Stalin ; Volz, Asisa ; Wohlsein, Peter ; Smits, Saskia L. ; Schipper, Debby ; Bestebroer, Theo M. ; Okba, Nisreen ; Fux, Robert ; Bensaid, Albert ; Foz, David Solanes ; Kuiken, Thijs ; Baumgärtner, Wolfgang ; Segalés, Joaquim ; Sutter, Gerd ; Osterhaus, Albert D. M. E.</creatorcontrib><description>Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aad1283</identifier><identifier>PMID: 26678878</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - immunology ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Camelpox virus ; Camels ; Camelus - virology ; Coronavirus ; Coronavirus Infections - prevention & control ; Coronavirus Infections - veterinary ; Disease Outbreaks - prevention & control ; Disorders ; Excretion ; Humans ; Hygiene ; Middle East Respiratory Syndrome Coronavirus - physiology ; Poxvirus ; Reduction ; Respiratory diseases ; RNA, Viral - immunology ; Spike Glycoprotein, Coronavirus - genetics ; Spike Glycoprotein, Coronavirus - immunology ; Transmissions (automotive) ; Vaccines ; Vaccinia virus ; Vaccinia virus - genetics ; Vaccinia virus - immunology ; Viral Vaccines - immunology ; Virus Shedding - immunology ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6268), p.77-81</ispartof><rights>Copyright © 2016 American Association for the Advancement of Science</rights><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Copyright © 2016, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-729ce78cf3900f9753ec26b50cb5efdf4a0bf9fd5761829a1def3219a0f0a0b53</citedby><cites>FETCH-LOGICAL-c454t-729ce78cf3900f9753ec26b50cb5efdf4a0bf9fd5761829a1def3219a0f0a0b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24741400$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24741400$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26678878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haagmans, Bart L.</creatorcontrib><creatorcontrib>van den Brand, Judith M. A.</creatorcontrib><creatorcontrib>Raj, V. Stalin</creatorcontrib><creatorcontrib>Volz, Asisa</creatorcontrib><creatorcontrib>Wohlsein, Peter</creatorcontrib><creatorcontrib>Smits, Saskia L.</creatorcontrib><creatorcontrib>Schipper, Debby</creatorcontrib><creatorcontrib>Bestebroer, Theo M.</creatorcontrib><creatorcontrib>Okba, Nisreen</creatorcontrib><creatorcontrib>Fux, Robert</creatorcontrib><creatorcontrib>Bensaid, Albert</creatorcontrib><creatorcontrib>Foz, David Solanes</creatorcontrib><creatorcontrib>Kuiken, Thijs</creatorcontrib><creatorcontrib>Baumgärtner, Wolfgang</creatorcontrib><creatorcontrib>Segalés, Joaquim</creatorcontrib><creatorcontrib>Sutter, Gerd</creatorcontrib><creatorcontrib>Osterhaus, Albert D. M. E.</creatorcontrib><title>An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Middle East respiratory syndrome coronavirus (MERS-CoV) infections have led to an ongoing outbreak in humans, which was fueled by multiple zoonotic MERS-CoV introductions from dromedary camels. In addition to the implementation of hygiene measures to limit further camel-to-human and human-to-human transmissions, vaccine-mediated reduction of MERS-CoV spread from the animal reservoir may be envisaged. Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.</description><subject>Animals</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Camelpox virus</subject><subject>Camels</subject><subject>Camelus - virology</subject><subject>Coronavirus</subject><subject>Coronavirus Infections - prevention & control</subject><subject>Coronavirus Infections - veterinary</subject><subject>Disease Outbreaks - prevention & control</subject><subject>Disorders</subject><subject>Excretion</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Middle East Respiratory Syndrome Coronavirus - physiology</subject><subject>Poxvirus</subject><subject>Reduction</subject><subject>Respiratory diseases</subject><subject>RNA, Viral - immunology</subject><subject>Spike Glycoprotein, Coronavirus - genetics</subject><subject>Spike Glycoprotein, Coronavirus - immunology</subject><subject>Transmissions (automotive)</subject><subject>Vaccines</subject><subject>Vaccinia virus</subject><subject>Vaccinia virus - genetics</subject><subject>Vaccinia virus - immunology</subject><subject>Viral Vaccines - immunology</subject><subject>Virus Shedding - immunology</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtPHDEURq2IKCyQOhXIEg3NwLU9fpVoxSMSERIJaUcez7WY1e54sWcQ-fc47CaRaELl4px7bX8fIV8YnDLG1Vn2PQ4eT53rGDfiA5kxsLKyHMQOmQEIVRnQcpfs5bwAKMyKT2SXK6WN0WZG_PlAYxof4jo-P_VpylXrMnb0yXnfD0gTdpPHTF8ZxWefcOzjQF0YMdFvF3ffq3n8SfshoH8F_UC7FFfYufSLerfCZT4gH4NbZvy8PffJ_eXFj_l1dXN79XV-flP5WtZjpbn1qI0PwgIEq6VAz1UrwbcSQxdqB22woZNaMcOtYx0GwZl1EKAgKfbJyWbvOsXHCfPYrPrscbl0A8YpN2VKSlUSsO9QwSjDuRb_V8tDAUyJuajHb9RFnNJQ_ryxlCwVFOtsY_kUc04YmnXqVyWuhkHzu9Vm22qzbbVMHG33Tm1J9q__p8YiHG6ERR5j-sdrXbO6XPkC6C2pIQ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Haagmans, Bart L.</creator><creator>van den Brand, Judith M. 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Here we show that a modified vaccinia virus Ankara (MVA) vaccine expressing the MERS-CoV spike protein confers mucosal immunity in dromedary camels. Compared with results for control animals, we observed a significant reduction of excreted infectious virus and viral RNA transcripts in vaccinated animals upon MERS-CoV challenge. Protection correlated with the presence of serum neutralizing antibodies to MERS-CoV. Induction of MVA-specific antibodies that cross-neutralize camelpox virus would also provide protection against camelpox.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>26678878</pmid><doi>10.1126/science.aad1283</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6268), p.77-81 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Camelpox virus Camels Camelus - virology Coronavirus Coronavirus Infections - prevention & control Coronavirus Infections - veterinary Disease Outbreaks - prevention & control Disorders Excretion Humans Hygiene Middle East Respiratory Syndrome Coronavirus - physiology Poxvirus Reduction Respiratory diseases RNA, Viral - immunology Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Transmissions (automotive) Vaccines Vaccinia virus Vaccinia virus - genetics Vaccinia virus - immunology Viral Vaccines - immunology Virus Shedding - immunology Viruses |
| title | An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels |
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