Biofunctionalization of titanium with bacitracin immobilization shows potential for anti-bacteria, osteogenesis and reduction of macrophage inflammation

[Display omitted] •The bacitracin can resist infection and promote hBMSC osteogenic differentiation.•The bacitracin can be covalently immobilized on the titanium.•The bacitracin-modified titanium has multiple biofunctions. Titanium has been widely used in the orthopedic and dental fields, however, t...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-09, Vol.145, p.728-739
Hauptverfasser:	Nie, Bin’en, Ao, Haiyong, Zhou, Jianliang, Tang, Tingting, Yue, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-bacteria Antiinfectives and antibacterials Bacitracin Bacitracin - adverse effects Bacitracin - chemistry Bacitracin - pharmacology Bacteria Biocompatibility Biofunctionalization Biomedical materials Bone Marrow Cells - drug effects Cell Differentiation - drug effects Cells, Cultured Covalence Differentiation Humans Inflammation - metabolism Macrophage inflammation Macrophages - drug effects Macrophages - metabolism Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Methicillin-Resistant Staphylococcus aureus - drug effects Microscopy, Electrochemical, Scanning Osteogenesis Osteogenesis - drug effects Photoelectron Spectroscopy Scanning electron microscopy Staphylococcus aureus Staphylococcus aureus - drug effects Titanium Titanium - chemistry Titanium base alloys
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