Derivation of the critical effect size/benchmark response for the dose-response analysis of the uptake of radioactive iodine in the human thyroid

•Intra-individual variation in the 24-h uptake of iodine by the thyroid is examined.•For euthyroid adult subjects, a between-days difference of 20% is concluded.•This inherent variation decreases the precision of relative RAIU data.•A critical effect size (CES/BMR) of 20% is proposed for benchmark d...

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Veröffentlicht in:	Toxicology letters 2016-08, Vol.257, p.38-43
Hauptverfasser:	Weterings, Peter J.J.M., Loftus, Christine, Lewandowski, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benchmark dose analysis Benchmark response Benchmarking Biological Transport Chlorates - adverse effects Critical effect size Dose-Response Relationship, Drug Hormones Human behavior Humans Inhibition Intra-individual variation Iodine Iodine Radioisotopes - metabolism No-Observed-Adverse-Effect Level Perchlorate Perchlorates - adverse effects Predictive Value of Tests Pretreatment Radioiodine RAIU Reproducibility of Results Risk Risk Assessment TDI Thyroid Thyroid Function Tests - standards Thyroid Gland - drug effects Thyroid Gland - metabolism Uptakes
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