Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer

Objective To investigate the effect of parthenolide on apoptosis and autophagy and to study the role of the PI3K/Akt signaling pathway in cervical cancer. Results Parthenolide inhibits HeLa cell viability in a dose dependent-manner and was confirmed by MTT assay. Parthenolide (6 µM) induces mitochon...

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Veröffentlicht in:	Biotechnology letters 2016-08, Vol.38 (8), p.1251-1260
Hauptverfasser:	Jeyamohan, Sridharan, Moorthy, Rajesh Kannan, Kannan, Mahesh Kumar, Arockiam, Antony Joseph Velanganni
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Apoptosis Apoptosis - drug effects Applied Microbiology Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Biotechnology Cancer Cervical cancer Chemical compounds Female HeLa Cells Herbal medicine Humans Life Sciences Membranes Microbiology Original Research Paper Pathways Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Retarding Sesquiterpenes - pharmacology Signal Transduction - drug effects Uterine Cervical Neoplasms - metabolism
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