A maleness gene in the malaria mosquito Anopheles gambiae
The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome–linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-07, Vol.353 (6294), p.67-69 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Krzywinska, Elzbieta Dennison, Nathan J. Lycett, Gareth J. Krzywinski, Jaroslaw |
| description | The molecular pathways controlling gender are highly variable and have been identified in only a few nonmammalian model species. In many insects, maleness is conferred by a Y chromosome–linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae. Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. This female-killing property may be an invaluable tool for creation of conditional male-only transgenic Anopheles strains for malaria control programs. |
| doi_str_mv | 10.1126/science.aaf5605 |
| format | Article |
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In many insects, maleness is conferred by a Y chromosome–linked M factor of unknown nature. We have isolated and characterized a gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae. Yob, activated at the beginning of zygotic transcription and expressed throughout a male's life, controls male-specific splicing of the doublesex gene. Silencing embryonic Yob expression is male-lethal, whereas ectopic embryonic delivery of Yob transcripts yields male-only broods. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Alternative Splicing Animals Animals, Genetically Modified - genetics Anopheles - embryology Anopheles - genetics Anopheles gambiae Aquatic insects Chromosomes Disease control Embryology Embryos Females Gene Silencing Genes Genes, Lethal Insect Proteins - genetics Insect Vectors - genetics Malaria Malaria - parasitology Male Males Mathematical models Mosquitoes Parasites Sex Sex Determination Processes - genetics Transcription, Genetic Vector-borne diseases Y Chromosome - genetics |
| title | A maleness gene in the malaria mosquito Anopheles gambiae |
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