Characterisation of stresses on microcarriers in a stirred bioreactor

•Hydrodynamics of a stirred suspension bioreactor is captured through CFD simulation.•Blended LES presented to account for free surface effects in a single-phase model.•Lagrangian particle tracking used to measure shear stress exposure of microcarriers.•Stresses from model linked to established stem...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Applied mathematical modelling 2016-08, Vol.40 (15-16), p.6787-6804
Hauptverfasser:	Berry, J.D., Liovic, P., Šutalo, I.D., Stewart, R.L., Glattauer, V., Meagher, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioreactors Computational fluid dynamics Culture Impellers Large eddy simulation Mathematical models Microcarriers Shear stress Stem cells Stresses Suspension bioreactor Turbulent flow
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!