Synthesis and characterization of CaP/Col composite scaffolds for load-bearing bone tissue engineering
Porous calcium phosphate (CaP) ceramics are widely used in bone tissue engineering due to their excellent biological properties. However, the inherent brittleness of CaP ceramics has restricted their applications in the repair of load-bearing bones. This study aimed to improve the mechanical strengt...
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| Veröffentlicht in: | Composites. Part B, Engineering Engineering, 2014-06, Vol.62, p.242-248 |
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| container_title | Composites. Part B, Engineering |
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| creator | Zhou, C.C. Ye, X.J. Fan, Y.J. Qing, F.Z. Chen, H.J. Zhang, X.D. |
| description | Porous calcium phosphate (CaP) ceramics are widely used in bone tissue engineering due to their excellent biological properties. However, the inherent brittleness of CaP ceramics has restricted their applications in the repair of load-bearing bones. This study aimed to improve the mechanical strength of CaP-based scaffolds by compositing CaP with collagen (Col). In this study, the influences of CaP porous structure, collagen content and cross-linking method on scaffolds mechanical strength were investigated. The morphologies of the composites were characterized by scanning electron microscope, and the mechanical properties of the scaffolds were assessed by dynamic mechanical analysis. The biocompatibility of the scaffolds was evaluated by culturing human bone marrow mesenchymal stem cells (MSCs) in vitro. The results show that the mechanical properties of scaffolds can be significantly improved by optimizing composite processes. Furthermore, remarkable viability and proliferation of MSCs on scaffolds was observed, which demonstrated good biocompatibility of the scaffolds. These results suggest that CaP/Col composite can be a promising scaffold for repair of load-bearing bones. |
| doi_str_mv | 10.1016/j.compositesb.2014.03.008 |
| format | Article |
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However, the inherent brittleness of CaP ceramics has restricted their applications in the repair of load-bearing bones. This study aimed to improve the mechanical strength of CaP-based scaffolds by compositing CaP with collagen (Col). In this study, the influences of CaP porous structure, collagen content and cross-linking method on scaffolds mechanical strength were investigated. The morphologies of the composites were characterized by scanning electron microscope, and the mechanical properties of the scaffolds were assessed by dynamic mechanical analysis. The biocompatibility of the scaffolds was evaluated by culturing human bone marrow mesenchymal stem cells (MSCs) in vitro. The results show that the mechanical properties of scaffolds can be significantly improved by optimizing composite processes. Furthermore, remarkable viability and proliferation of MSCs on scaffolds was observed, which demonstrated good biocompatibility of the scaffolds. These results suggest that CaP/Col composite can be a promising scaffold for repair of load-bearing bones.</description><identifier>ISSN: 1359-8368</identifier><identifier>EISSN: 1879-1069</identifier><identifier>DOI: 10.1016/j.compositesb.2014.03.008</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>A. Ceramic–matrix composites (CMCs) ; Applied sciences ; B. Mechanical properties ; B. Porosity ; Biocompatibility ; Biological and medical sciences ; Bones ; Ceramics ; Composites ; E. Sintering ; Exact sciences and technology ; Forms of application and semi-finished materials ; Mechanical properties ; Medical sciences ; Polymer industry, paints, wood ; Repair ; Scaffolds ; Scanning electron microscopy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. Equipments ; Tissue engineering</subject><ispartof>Composites. 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Part B, Engineering</title><description>Porous calcium phosphate (CaP) ceramics are widely used in bone tissue engineering due to their excellent biological properties. However, the inherent brittleness of CaP ceramics has restricted their applications in the repair of load-bearing bones. This study aimed to improve the mechanical strength of CaP-based scaffolds by compositing CaP with collagen (Col). In this study, the influences of CaP porous structure, collagen content and cross-linking method on scaffolds mechanical strength were investigated. The morphologies of the composites were characterized by scanning electron microscope, and the mechanical properties of the scaffolds were assessed by dynamic mechanical analysis. The biocompatibility of the scaffolds was evaluated by culturing human bone marrow mesenchymal stem cells (MSCs) in vitro. The results show that the mechanical properties of scaffolds can be significantly improved by optimizing composite processes. Furthermore, remarkable viability and proliferation of MSCs on scaffolds was observed, which demonstrated good biocompatibility of the scaffolds. These results suggest that CaP/Col composite can be a promising scaffold for repair of load-bearing bones.</description><subject>A. Ceramic–matrix composites (CMCs)</subject><subject>Applied sciences</subject><subject>B. Mechanical properties</subject><subject>B. Porosity</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Bones</subject><subject>Ceramics</subject><subject>Composites</subject><subject>E. Sintering</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>Mechanical properties</subject><subject>Medical sciences</subject><subject>Polymer industry, paints, wood</subject><subject>Repair</subject><subject>Scaffolds</subject><subject>Scanning electron microscopy</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. 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This study aimed to improve the mechanical strength of CaP-based scaffolds by compositing CaP with collagen (Col). In this study, the influences of CaP porous structure, collagen content and cross-linking method on scaffolds mechanical strength were investigated. The morphologies of the composites were characterized by scanning electron microscope, and the mechanical properties of the scaffolds were assessed by dynamic mechanical analysis. The biocompatibility of the scaffolds was evaluated by culturing human bone marrow mesenchymal stem cells (MSCs) in vitro. The results show that the mechanical properties of scaffolds can be significantly improved by optimizing composite processes. Furthermore, remarkable viability and proliferation of MSCs on scaffolds was observed, which demonstrated good biocompatibility of the scaffolds. 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| subjects | A. Ceramic–matrix composites (CMCs) Applied sciences B. Mechanical properties B. Porosity Biocompatibility Biological and medical sciences Bones Ceramics Composites E. Sintering Exact sciences and technology Forms of application and semi-finished materials Mechanical properties Medical sciences Polymer industry, paints, wood Repair Scaffolds Scanning electron microscopy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Tissue engineering |
| title | Synthesis and characterization of CaP/Col composite scaffolds for load-bearing bone tissue engineering |
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