SweepFinder2: increased sensitivity, robustness and flexibility
SweepFinder is a widely used program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the confounding effects of mutation rate varia...
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| Veröffentlicht in: | Bioinformatics 2016-06, Vol.32 (12), p.1895-1897 |
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| container_issue | 12 |
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| container_title | Bioinformatics |
| container_volume | 32 |
| creator | DeGiorgio, Michael Huber, Christian D Hubisz, Melissa J Hellmann, Ines Nielsen, Rasmus |
| description | SweepFinder is a widely used program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the confounding effects of mutation rate variation and background selection. Moreover, SweepFinder2 has increased flexibility that enables the user to specify test sites, set the distance between test sites and utilize a recombination map.
SweepFinder2 is a freely-available (www.personal.psu.edu/mxd60/sf2.html) software package that is written in C and can be run from a Unix command line.
mxd60@psu.edu. |
| doi_str_mv | 10.1093/bioinformatics/btw051 |
| format | Article |
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SweepFinder2 is a freely-available (www.personal.psu.edu/mxd60/sf2.html) software package that is written in C and can be run from a Unix command line.
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SweepFinder2 is a freely-available (www.personal.psu.edu/mxd60/sf2.html) software package that is written in C and can be run from a Unix command line.
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| ispartof | Bioinformatics, 2016-06, Vol.32 (12), p.1895-1897 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central; Alma/SFX Local Collection |
| subjects | Bioinformatics Commands Evolution, Molecular Flexibility Humans Likelihood Functions Mutation Rate Mutations Robustness Selection, Genetic Software Software packages Summaries UNIX (operating system) |
| title | SweepFinder2: increased sensitivity, robustness and flexibility |
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