APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

The expression of genes involved in p53-mediated apoptosis was studied using cDNA microarray after treating isogenic cell lines with either ionizing radiation or doxorubicin. Most of the known p53 transcriptional activation target genes clustered in a functional category defined by early and p53-dep...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-09, Vol.61 (18), p.6660-6664
Hauptverfasser:	ROBLES, Ana I, BEMMELS, Nicole A, FORAKER, Amy B, HARRIS, Curtis C
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death APAF-1 protein Apoptosis - genetics Apoptotic Protease-Activating Factor 1 Biological and medical sciences Cell Line Cell physiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Damage DNA microarrays doxorubicin Fundamental and applied biological sciences. Psychology Gene Expression Profiling Humans Lymphocytes - drug effects Lymphocytes - physiology Lymphocytes - radiation effects Molecular and cellular biology Multigene Family Oligonucleotide Array Sequence Analysis Proteins - genetics Transcriptional Activation - drug effects Transcriptional Activation - genetics Transcriptional Activation - radiation effects Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics
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