Central composite experimental design for the investigation of the influence of various conditions of anodisation on the amount of antimicrobial agent loaded on TiO sub(2) nanotubes

TiO sub(2) nanotubes on Ti substrate were prepared by electrochemical anodisation method. Central composite experimental design was used to design the experiments to investigate the influence of some variables on the loading of antibiotic gentamicin. A full quadratic model was used in order to find...

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Veröffentlicht in:Micro & nano letters 2015-08, Vol.10 (8), p.370-374
Hauptverfasser: Lotfi, M, Sabzi, R E, Bahram, M, Samadi, N
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Sabzi, R E
Bahram, M
Samadi, N
description TiO sub(2) nanotubes on Ti substrate were prepared by electrochemical anodisation method. Central composite experimental design was used to design the experiments to investigate the influence of some variables on the loading of antibiotic gentamicin. A full quadratic model was used in order to find out the influence of the variables and their possible interactions and finally to estimate the optimum conditions. Titanium rods were anodised in ethylene glycol containing different amounts of ammonium fluoride and water at different voltages and different anodising times. Antibacterial activity of the nanotubes prepared under the optimum condition was evaluated by a culture test with Staphylococcus aureus bacteria
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source Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Bacteria
Electric potential
Mathematical models
Nanostructure
Nanotubes
Optimization
Titanium
Titanium dioxide
title Central composite experimental design for the investigation of the influence of various conditions of anodisation on the amount of antimicrobial agent loaded on TiO sub(2) nanotubes
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