Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae

ABSTRACT Ginsenosides, the major bioactive components of Panax ginseng, are regarded as promising high‐value pharmaceutical compounds. In ginseng, ginsenosides are produced from their precursor protopanaxadiol. Recently, an artificial biosynthetic pathway of protopanaxadiol was built in Saccharomyce...

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Veröffentlicht in:	Biotechnology and bioengineering 2016-08, Vol.113 (8), p.1787-1795
Hauptverfasser:	Zhao, Fanglong, Bai, Peng, Liu, Ting, Li, Dashuai, Zhang, Xiangmei, Lu, Wenyu, Yuan, Yingjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis thaliana Bioengineering Bioreactors Catalytic activity Construction Cytochrome Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochromes P450 dammarenediol-II Fermentation Herbal medicine Metabolic Engineering - methods Panax ginseng Proteins protopanaxadiol protopanaxadiol synthase Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Sapogenins - analysis Sapogenins - metabolism Saponins - analysis Saponins - metabolism self-sufficient P450s synthetic biology Synthetic Biology - methods Triterpenes - analysis Triterpenes - metabolism Yeast Yeasts
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