Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy

The therapeutic potential of a nucleoside analog, gemcitabine, is severely compromised due to its rapid clearance from systemic circulation by enzymatic degradation into an inactive metabolite. In the present investigation, micelles based on polymer-drug conjugate were developed for gemcitabine and...

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Veröffentlicht in:	RSC advances 2016-01, Vol.6 (65), p.6126-6137
Hauptverfasser:	Khare, Vaibhav, Sakarchi, Wejdan Al, Gupta, Prem N, Curtis, Anthony D. M, Hoskins, Clare
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Chemical compounds Drugs Formulations Micelles Nucleosides Self assembly Tocopherol
Online-Zugang:	Volltext
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