Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein

Binding of metal ions is an important regulatory mechanism in proteins. Specifically, Zn 2+ binding to disordered regions commonly induces a disorder to order transition and gain of structure or oligomerization. Here we show that simultaneous binding of Zn 2+ ions has different effects on structured...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-01, Vol.7 (7), p.414-4147
Hauptverfasser:	Amartely, Hadar, David, Ahuvit, Shamir, Mai, Lebendiker, Mario, Izraeli, Shai, Friedler, Assaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Binding Chemistry Disorders Gain Government regulations Oligomerization Proteins Zinc
Online-Zugang:	Volltext
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