Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy
Two-armed lanthanide-binding tags induce significant, long-range paramagnetic effects in the NMR spectra of attached proteins. An enantiomeric pair of rigid, two-armed, cyclen-based tags are reported that produce markedly different effects from the same tagging site, allowing for the measurement of...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (51), p.7954-7957 |
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| container_issue | 51 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Lee, Michael D Dennis, Matthew L Swarbrick, James D Graham, Bim |
| description | Two-armed lanthanide-binding tags induce significant, long-range paramagnetic effects in the NMR spectra of attached proteins. An enantiomeric pair of rigid, two-armed, cyclen-based tags are reported that produce markedly different effects from the same tagging site, allowing for the measurement of complementary paramagnetic restraints for structural studies.
A new pair of two-armed lanthanide-binding tags provide distinct sets of structural restraints when attached to the same site of a protein. |
| doi_str_mv | 10.1039/c6cc02325h |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2016-01, Vol.52 (51), p.7954-7957 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1825519538 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Constraints Marking NMR spectroscopy Nuclear magnetic resonance Proteins Spectra Tags |
| title | Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy |
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