The cyclopropylimine rearrangement/Povarov reaction cascade for the assembly of pyrrolo[3,2-c]quinoline derivatives

The cyclopropylimine rearrangement/Povarov reaction cascade for the assembly of pyrrolo[3,2-c]quinoline derivatives

We disclose a reaction cascade involving cyclopropylimine rearrangement and the Povarov reaction for the synthesis of hexahydropyrroloquinolines from anilines and cyclopropyl aldehydes. This method provides facile and convenient access to pharmacologically significant pyrrolo[3,2-c]quinoline derivat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2016-01, Vol.18 (12), p.3503-3506
Hauptverfasser: Cai, Jinhui, Li, Feifei, Deng, Guo-Jun, Ji, Xiaochen, Huang, Huawen
Format: Artikel
Sprache:eng
Schlagworte:
Accessibility
Aniline
Assembly
Cascades
Derivatives
Organic compounds
Pharmacology
Synthesis (chemistry)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We disclose a reaction cascade involving cyclopropylimine rearrangement and the Povarov reaction for the synthesis of hexahydropyrroloquinolines from anilines and cyclopropyl aldehydes. This method provides facile and convenient access to pharmacologically significant pyrrolo[3,2-c]quinoline derivatives which are not easily accessible using the existing methods.
ISSN:1463-9262
1463-9270
DOI:10.1039/c6gc00779a