Dynamic light scattering (DLS)-based immunoassay for ultra-sensitive detection of tumor marker protein

Dynamic light scattering (DLS)-based immunoassay for ultra-sensitive detection of tumor marker protein

A novel dynamic light scattering (DLS)-based immunoassay that utilizes manganese dioxide nanosheet-modified gold nanoparticles (MnO 2 -GNPs) as an activatable nanoprobe has been developed to detect tumor markers down to femtomolar levels. With the help of manganese dioxide (MnO 2 ) nanosheet-modifie...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-06, Vol.52 (5), p.785-7853
Hauptverfasser: Li, Chao, Ma, Jiehua, Fan, Qiongxuan, Tao, Yaqin, Li, Genxi
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers, Tumor - analysis
Dynamic Light Scattering
Dynamics
Fluorescent Dyes - chemistry
Gold - chemistry
Humans
Immunoassay
Immunoassay - methods
Light scattering
Manganese Compounds - chemistry
Markers
Metal Nanoparticles - chemistry
Molecular Imaging
Nanoparticles
Nanostructure
Neoplasm Proteins - analysis
Oxides - chemistry
Proteins
Tumors
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Beschreibung
Zusammenfassung:A novel dynamic light scattering (DLS)-based immunoassay that utilizes manganese dioxide nanosheet-modified gold nanoparticles (MnO 2 -GNPs) as an activatable nanoprobe has been developed to detect tumor markers down to femtomolar levels. With the help of manganese dioxide (MnO 2 ) nanosheet-modified gold nanoparticles, a dynamic light scattering (DLS)-based immunoassay that can detect ultra-low levels of tumor marker protein is developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc02633h