In vitro mesenchymal stem cell response to a CO2 laser modified polymeric material
With an ageing world population it is becoming significantly apparent that there is a need to produce implants and platforms to manipulate stem cell growth on a pharmaceutical scale. This is needed to meet the socio-economic demands of many countries worldwide. This paper details one of the first ev...
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| Veröffentlicht in: | Materials Science & Engineering C 2016-10, Vol.67, p.727-736 |
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| creator | Waugh, D.G. Hussain, I. Lawrence, J. Smith, G.C. Cosgrove, D. Toccaceli, C. |
| description | With an ageing world population it is becoming significantly apparent that there is a need to produce implants and platforms to manipulate stem cell growth on a pharmaceutical scale. This is needed to meet the socio-economic demands of many countries worldwide. This paper details one of the first ever studies in to the manipulation of stem cell growth on CO2 laser surface treated nylon 6,6 highlighting its potential as an inexpensive platform to manipulate stem cell growth on a pharmaceutical scale. Through CO2 laser surface treatment discrete changes to the surfaces were made. That is, the surface roughness of the nylon 6,6 was increased by up to 4.3μm, the contact angle was modulated by up to 5° and the surface oxygen content increased by up to 1atom %. Following mesenchymal stem cell growth on the laser treated samples, it was identified that CO2 laser surface treatment gave rise to an enhanced response with an increase in viable cell count of up to 60,000cells/ml when compared to the as-received sample. The effect of surface parameters modified by the CO2 laser surface treatment on the mesenchymal stem cell response is also discussed along with potential trends that could be identified to govern the mesenchymal stem cell response. |
| doi_str_mv | 10.1016/j.msec.2016.05.055 |
| format | Article |
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This is needed to meet the socio-economic demands of many countries worldwide. This paper details one of the first ever studies in to the manipulation of stem cell growth on CO2 laser surface treated nylon 6,6 highlighting its potential as an inexpensive platform to manipulate stem cell growth on a pharmaceutical scale. Through CO2 laser surface treatment discrete changes to the surfaces were made. That is, the surface roughness of the nylon 6,6 was increased by up to 4.3μm, the contact angle was modulated by up to 5° and the surface oxygen content increased by up to 1atom %. Following mesenchymal stem cell growth on the laser treated samples, it was identified that CO2 laser surface treatment gave rise to an enhanced response with an increase in viable cell count of up to 60,000cells/ml when compared to the as-received sample. The effect of surface parameters modified by the CO2 laser surface treatment on the mesenchymal stem cell response is also discussed along with potential trends that could be identified to govern the mesenchymal stem cell response.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2016.05.055</identifier><identifier>PMID: 27287173</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adhesion ; Caprolactam - analogs & derivatives ; Caprolactam - chemistry ; Carbon dioxide lasers ; Cells, Cultured ; CO2 laser ; Contact angle ; Humans ; Lasers, Gas ; Materials science ; Materials Testing ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Nylons ; Pharmaceuticals ; Platforms ; Polymers - chemistry ; Stem cells ; Surface engineering ; Surface Properties ; Surface treatment ; Wettability</subject><ispartof>Materials Science & Engineering C, 2016-10, Vol.67, p.727-736</ispartof><rights>2016</rights><rights>Copyright © 2016. 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The effect of surface parameters modified by the CO2 laser surface treatment on the mesenchymal stem cell response is also discussed along with potential trends that could be identified to govern the mesenchymal stem cell response.</description><subject>Adhesion</subject><subject>Caprolactam - analogs & derivatives</subject><subject>Caprolactam - chemistry</subject><subject>Carbon dioxide lasers</subject><subject>Cells, Cultured</subject><subject>CO2 laser</subject><subject>Contact angle</subject><subject>Humans</subject><subject>Lasers, Gas</subject><subject>Materials science</subject><subject>Materials Testing</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Nylons</subject><subject>Pharmaceuticals</subject><subject>Platforms</subject><subject>Polymers - chemistry</subject><subject>Stem cells</subject><subject>Surface engineering</subject><subject>Surface Properties</subject><subject>Surface treatment</subject><subject>Wettability</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMotlb_gAfJ0cvWfGyaLHiR4kehUBA9h5jMYspmd022hf57s7SehYF3GB6GmfdF6JaSOSV08bCdhwR2znI_JyKXOENTqiQvCK3oOZqSiqmirDidoKuUtoQsFJfsEk2YZEpSyafofdXivR9ihwMkaO33IZgGpwECttA0OELquzYBHjps8HLDcGMSRBw652sPDvddcwgQvcXBDFlNc40uatMkuDnpDH2-PH8s34r15nW1fFoXwHk5FBKkE0pYxRZKCl6XYBhzNTDHZJ2HRFUgVaU4d6rmlgE4ScBWUNaGgFB8hu6Pe_vY_ewgDTr4NB5tWuh2SVPFhKClKsv_UVkJpagsaUbvTujuK4DTffTBxIP-sywDj0cA8m97D1En67Nz4HwEO2jXeU2JHhPSWz0mpMeENBG5BP8FcWmCpQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Waugh, D.G.</creator><creator>Hussain, I.</creator><creator>Lawrence, J.</creator><creator>Smith, G.C.</creator><creator>Cosgrove, D.</creator><creator>Toccaceli, C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-7186-2797</orcidid></search><sort><creationdate>20161001</creationdate><title>In vitro mesenchymal stem cell response to a CO2 laser modified polymeric material</title><author>Waugh, D.G. ; 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| ispartof | Materials Science & Engineering C, 2016-10, Vol.67, p.727-736 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adhesion Caprolactam - analogs & derivatives Caprolactam - chemistry Carbon dioxide lasers Cells, Cultured CO2 laser Contact angle Humans Lasers, Gas Materials science Materials Testing Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Nylons Pharmaceuticals Platforms Polymers - chemistry Stem cells Surface engineering Surface Properties Surface treatment Wettability |
| title | In vitro mesenchymal stem cell response to a CO2 laser modified polymeric material |
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