Controlled release from thermo-sensitive PNVCL-co-MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug

The thermo-sensitive copolymer poly(N-vinylcaprolactam-co-methacrylic acid) (PNVCL-co-MAA) was synthesized by free radical polymerization and the resulting nanofibers were fabricated using an electrospinning process. The molecular weight of the copolymer was adjusted by varying the content of methac...

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Veröffentlicht in:Materials Science & Engineering C 2016-10, Vol.67, p.581-589
Hauptverfasser: Liu, Lin, Bai, Shaoqing, Yang, Huiqin, Li, Shubai, Quan, Jing, Zhu, Limin, Nie, Huali
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container_start_page 581
container_title Materials Science & Engineering C
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creator Liu, Lin
Bai, Shaoqing
Yang, Huiqin
Li, Shubai
Quan, Jing
Zhu, Limin
Nie, Huali
description The thermo-sensitive copolymer poly(N-vinylcaprolactam-co-methacrylic acid) (PNVCL-co-MAA) was synthesized by free radical polymerization and the resulting nanofibers were fabricated using an electrospinning process. The molecular weight of the copolymer was adjusted by varying the content of methacrylic acid (MAA) while keeping that of N-vinylcaprolactam (NVCL) constant. Hydrophilic captopril and hydrophobic ketoprofen were used as model drugs, and PNVCL-co-MAA nanofibers were used as the drug carrier to investigate the effects of drug on its release properties from nanofibers at different temperatures. The results showed that slow release over several hours was observed at 40°C (above the lower critical solution temperature (LCST) of PNVCL-co-MAA), while the drugs exhibited a burst release of several seconds at 20°C (below the LCST). Drug release slowed with increasing content of the hydrophobic monomer NVCL. The hydrophilic captopril was released at a higher rate than the hydrophobic ketoprofen. The drug release characteristics were dependent on the temperature, the portion of hydrophilic groups and hydrophobic groups in the copolymer and hydrophilicity/hydrophobicity of drug. Study on the mechanism of release showed that Korsmeyer–Peppas model as a major drug release mechanism. Given these results, the PNVCL-co-MAA copolymers are proposed to have useful applications in intellectual drug delivery systems. [Display omitted] •A series of copolymers with different various molecular weights were synthesized.•Novel thermo-sensitive and biocompatible electrospun nanofibers were fabricated.•Effects of hydrophilicity/hydrophobicity of a drug on release were investigated.•The drug release mechanism from nanofibers was discussed.
doi_str_mv 10.1016/j.msec.2016.05.083
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The molecular weight of the copolymer was adjusted by varying the content of methacrylic acid (MAA) while keeping that of N-vinylcaprolactam (NVCL) constant. Hydrophilic captopril and hydrophobic ketoprofen were used as model drugs, and PNVCL-co-MAA nanofibers were used as the drug carrier to investigate the effects of drug on its release properties from nanofibers at different temperatures. The results showed that slow release over several hours was observed at 40°C (above the lower critical solution temperature (LCST) of PNVCL-co-MAA), while the drugs exhibited a burst release of several seconds at 20°C (below the LCST). Drug release slowed with increasing content of the hydrophobic monomer NVCL. The hydrophilic captopril was released at a higher rate than the hydrophobic ketoprofen. The drug release characteristics were dependent on the temperature, the portion of hydrophilic groups and hydrophobic groups in the copolymer and hydrophilicity/hydrophobicity of drug. Study on the mechanism of release showed that Korsmeyer–Peppas model as a major drug release mechanism. Given these results, the PNVCL-co-MAA copolymers are proposed to have useful applications in intellectual drug delivery systems. [Display omitted] •A series of copolymers with different various molecular weights were synthesized.•Novel thermo-sensitive and biocompatible electrospun nanofibers were fabricated.•Effects of hydrophilicity/hydrophobicity of a drug on release were investigated.•The drug release mechanism from nanofibers was discussed.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2016.05.083</identifier><identifier>PMID: 27287157</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Caprolactam - analogs &amp; derivatives ; Caprolactam - chemistry ; Captopril - chemistry ; Captopril - pharmacokinetics ; Controlled release ; Copolymers ; Delayed-Action Preparations - chemistry ; Delayed-Action Preparations - pharmacokinetics ; Drug delivery ; Drug delivery systems ; Drugs ; Electrospinning ; Hydrophilicity ; Hydrophobicity ; Ketoprofen ; Ketoprofen - chemistry ; Ketoprofen - pharmacokinetics ; Nanofiber ; Nanofibers ; Nanofibers - chemistry ; Polymers - chemistry ; Polymethacrylic Acids - chemistry ; Thermo-sensitive</subject><ispartof>Materials Science &amp; Engineering C, 2016-10, Vol.67, p.581-589</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. 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The molecular weight of the copolymer was adjusted by varying the content of methacrylic acid (MAA) while keeping that of N-vinylcaprolactam (NVCL) constant. Hydrophilic captopril and hydrophobic ketoprofen were used as model drugs, and PNVCL-co-MAA nanofibers were used as the drug carrier to investigate the effects of drug on its release properties from nanofibers at different temperatures. The results showed that slow release over several hours was observed at 40°C (above the lower critical solution temperature (LCST) of PNVCL-co-MAA), while the drugs exhibited a burst release of several seconds at 20°C (below the LCST). Drug release slowed with increasing content of the hydrophobic monomer NVCL. The hydrophilic captopril was released at a higher rate than the hydrophobic ketoprofen. The drug release characteristics were dependent on the temperature, the portion of hydrophilic groups and hydrophobic groups in the copolymer and hydrophilicity/hydrophobicity of drug. 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Study on the mechanism of release showed that Korsmeyer–Peppas model as a major drug release mechanism. Given these results, the PNVCL-co-MAA copolymers are proposed to have useful applications in intellectual drug delivery systems. [Display omitted] •A series of copolymers with different various molecular weights were synthesized.•Novel thermo-sensitive and biocompatible electrospun nanofibers were fabricated.•Effects of hydrophilicity/hydrophobicity of a drug on release were investigated.•The drug release mechanism from nanofibers was discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27287157</pmid><doi>10.1016/j.msec.2016.05.083</doi><tpages>9</tpages></addata></record>
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subjects Caprolactam - analogs & derivatives
Caprolactam - chemistry
Captopril - chemistry
Captopril - pharmacokinetics
Controlled release
Copolymers
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - pharmacokinetics
Drug delivery
Drug delivery systems
Drugs
Electrospinning
Hydrophilicity
Hydrophobicity
Ketoprofen
Ketoprofen - chemistry
Ketoprofen - pharmacokinetics
Nanofiber
Nanofibers
Nanofibers - chemistry
Polymers - chemistry
Polymethacrylic Acids - chemistry
Thermo-sensitive
title Controlled release from thermo-sensitive PNVCL-co-MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug
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