PEG stabilized DNA - poly(ferrocenylsilane) polyplexes for gene delivery

PEG stabilized DNA - poly(ferrocenylsilane) polyplexes for gene delivery

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (49), p.7707-7710
Hauptverfasser: Zoetebier, B, Sohrabi, A, Lou, B, Hempenius, M A, Hennink, W E, Vancso, G J
Format: Artikel
Sprache:eng
Schlagworte:
Agglomeration
Biocompatibility
Condensation
Deoxyribonucleic acid
DNA - chemistry
DNA - genetics
Drug Carriers - chemistry
Drug Carriers - pharmacology
Ferrous Compounds - chemistry
Genes
Materials Testing
Polyethyleneimine
Polyethyleneimine - chemistry
Protein adsorption
Silanes - chemistry
Transfection
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Zusammenfassung:Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc02733d