Enzymatic recycling of ascorbic acid from dehydroascorbic acid by glutathione-like peptides in the extracellular loops of aminergic G-protein coupled receptors

The intracellular recycling of ascorbic acid from dehydroascorbic acid by the glutathione–glutathione reductase system has been well‐characterized. We propose that extracellular recycling of ascorbic acid is performed in a similar manner by cysteine‐rich, glutathione‐like regions of the first and se...

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Veröffentlicht in:	Journal of molecular recognition 2016-07, Vol.29 (7), p.296-302
Hauptverfasser:	Root-Bernstein, Robert, Fewins, Jenna, Rhinesmith, Tyler, Koch, Ariana, Dillon, Patrick F.
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenergic receptor antioxidant ascorbate recycling Ascorbic acid Ascorbic Acid - metabolism Binding Sites Cysteine Cysteine - chemistry dehydroascorbate Dehydroascorbic Acid - metabolism dopamine receptor extracellular Glutathione Glutathione - chemistry Glutathione - metabolism histamine receptor Insulin Kinetics Methionine - chemistry Models, Molecular Oxidation Oxidation-Reduction Peptides Peptides - chemical synthesis Peptides - chemistry Peptides - metabolism Protein Structure, Secondary reactive oxygen species Receptors Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Recycling
Online-Zugang:	Volltext
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