Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications
Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearly all current antiseptic agents before their conti...
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| Veröffentlicht in: | Advanced healthcare materials 2016-06, Vol.5 (11), p.1282-1289 |
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| creator | Zakrewsky, Michael Banerjee, Amrita Apte, Sanjana Kern, Theresa L. Jones, Mattie R. Sesto, Rico E. Del Koppisch, Andrew T. Fox, David T. Mitragotri, Samir |
| description | Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearly all current antiseptic agents before their continued use can be allowed. This vulnerable position calls for urgent identification of novel antiseptic agents. Recently, the ability of a deep eutectic, Choline And Geranate (CAGE), to treat biofilms of Pseudomonas aeruginosa and Salmonella enterica was demonstrated. Here it is reported that CAGE exhibits broad‐spectrum antimicrobial activity against a number of drug‐resistant bacteria, fungi, and viruses including clinical isolates of Mycobacterium tuberculosis, Staphylococcus aureus, and Candida albicans as well as laboratory strains of Herpes Simplex Virus. Studies in human keratinocytes and mice show that CAGE affords negligible local or systemic toxicity, and an ≈180–14 000‐fold improved efficacy/toxicity ratio over currently used antiseptic agents. Further, CAGE penetrates deep into the dermis and treats pathogens located in deep skin layers as confirmed by the ability of CAGE in vivo to treat Propionibacterium acnes infection. In combination, the results clearly demonstrate CAGE holds promise as a transformative platform antiseptic agent for preventive as well as therapeutic applications.
A unique formulation of choline, geranate, and geranic acid eutectic solvent (CAGE) holds promise as a transformative platform for the prevention and treatment of microbial infections. |
| doi_str_mv | 10.1002/adhm.201600086 |
| format | Article |
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A unique formulation of choline, geranate, and geranic acid eutectic solvent (CAGE) holds promise as a transformative platform for the prevention and treatment of microbial infections.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Infective Agents, Local - pharmacology</subject><subject>antimicrobial resistance</subject><subject>Antiseptics</subject><subject>Bacteria</subject><subject>Bacteria - drug effects</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>beacterial infections</subject><subject>Biofilms - drug effects</subject><subject>Cage</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candidiasis - drug therapy</subject><subject>Candidiasis - microbiology</subject><subject>Cell Line</subject><subject>Choline</subject><subject>Choline - pharmacology</subject><subject>drug delivery</subject><subject>Eutectics</subject><subject>Female</subject><subject>Herpes simplex virus</subject><subject>Humans</subject><subject>infection prevention</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Mycobacterium tuberculosis</subject><subject>Pathogens</subject><subject>Propionibacterium acnes</subject><subject>Pseudomonas aeruginosa</subject><subject>Rats, Sprague-Dawley</subject><subject>Reagents</subject><subject>Salmonella enterica</subject><subject>Solvents - pharmacology</subject><subject>Staphylococcus aureus</subject><subject>Toxicity</subject><subject>Viruses</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURiMEolXpliWyxIZNBj_i13KYlmmlUh4tdGk5zg3jkklSOymt-PM4pIwQG9jceyWf70jWl2XPCV4QjOlrW222C4qJwBgr8Sjbp0TTnAquH-_uAu9lhzFeJwQLToQiT7M9KjTXivH97Mdq0zW-BWTbCq0h2NYOgI4AenQ8DuAG79BF19xCOyAbkUVvQmer_KJPT2HcomU7-Aj9hC2_TlDdBfQhwBTwt7P2cpO8PYy_oL5vvLOD79r4LHtS2ybC4cM-yD6_Pb5cneRn79enq-VZ7gRhIndlySmruXSltUqq0paY0QIKURVaOc0ZS5cUSuq6KCVYyUUBmLES185pxg6yV7O3D93NCHEwWx8dNI1toRujIYryQvE0_wPFSlLCJEnoy7_Q624MbfqIIVIXnFKJaaIWM-VCF2OA2vTBb224NwSbqUQzlWh2JabAiwftWG6h2uG_K0uAnoHvvoH7f-jM8ujk3Z_yfM76OMDdLmvDNyMkk9xcna-N-KTlx_PVlfnCfgLKSLcY</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Zakrewsky, Michael</creator><creator>Banerjee, Amrita</creator><creator>Apte, Sanjana</creator><creator>Kern, Theresa L.</creator><creator>Jones, Mattie R.</creator><creator>Sesto, Rico E. Del</creator><creator>Koppisch, Andrew T.</creator><creator>Fox, David T.</creator><creator>Mitragotri, Samir</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>201606</creationdate><title>Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications</title><author>Zakrewsky, Michael ; Banerjee, Amrita ; Apte, Sanjana ; Kern, Theresa L. ; Jones, Mattie R. ; Sesto, Rico E. 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Del</au><au>Koppisch, Andrew T.</au><au>Fox, David T.</au><au>Mitragotri, Samir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv. Healthcare Mater</addtitle><date>2016-06</date><risdate>2016</risdate><volume>5</volume><issue>11</issue><spage>1282</spage><epage>1289</epage><pages>1282-1289</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearly all current antiseptic agents before their continued use can be allowed. This vulnerable position calls for urgent identification of novel antiseptic agents. Recently, the ability of a deep eutectic, Choline And Geranate (CAGE), to treat biofilms of Pseudomonas aeruginosa and Salmonella enterica was demonstrated. Here it is reported that CAGE exhibits broad‐spectrum antimicrobial activity against a number of drug‐resistant bacteria, fungi, and viruses including clinical isolates of Mycobacterium tuberculosis, Staphylococcus aureus, and Candida albicans as well as laboratory strains of Herpes Simplex Virus. Studies in human keratinocytes and mice show that CAGE affords negligible local or systemic toxicity, and an ≈180–14 000‐fold improved efficacy/toxicity ratio over currently used antiseptic agents. Further, CAGE penetrates deep into the dermis and treats pathogens located in deep skin layers as confirmed by the ability of CAGE in vivo to treat Propionibacterium acnes infection. In combination, the results clearly demonstrate CAGE holds promise as a transformative platform antiseptic agent for preventive as well as therapeutic applications.
A unique formulation of choline, geranate, and geranic acid eutectic solvent (CAGE) holds promise as a transformative platform for the prevention and treatment of microbial infections.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26959835</pmid><doi>10.1002/adhm.201600086</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - pharmacology Anti-Infective Agents, Local - pharmacology antimicrobial resistance Antiseptics Bacteria Bacteria - drug effects Bacterial Infections - drug therapy Bacterial Infections - microbiology beacterial infections Biofilms - drug effects Cage Candida albicans Candida albicans - drug effects Candidiasis - drug therapy Candidiasis - microbiology Cell Line Choline Choline - pharmacology drug delivery Eutectics Female Herpes simplex virus Humans infection prevention Male Mice Mice, Hairless Microbial Sensitivity Tests - methods Mycobacterium tuberculosis Pathogens Propionibacterium acnes Pseudomonas aeruginosa Rats, Sprague-Dawley Reagents Salmonella enterica Solvents - pharmacology Staphylococcus aureus Toxicity Viruses |
| title | Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications |
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