Mucoadhesion: A promising approach in drug delivery system
Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabol...
Gespeichert in:
| Veröffentlicht in: | Reactive & functional polymers 2016-03, Vol.100, p.151-172 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | |
| container_start_page | 151 |
| container_title | Reactive & functional polymers |
| container_volume | 100 |
| creator | Mansuri, Shakir Kesharwani, Prashant Jain, Keerti Tekade, Rakesh K. Jain, N.K. |
| description | Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems. |
| doi_str_mv | 10.1016/j.reactfunctpolym.2016.01.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1825468829</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1381514816300104</els_id><sourcerecordid>1825468829</sourcerecordid><originalsourceid>FETCH-LOGICAL-c502t-7e5ccbdafc20f668f627fa4e813b38d756f39daf3ec753ed7944b7edc91bcf053</originalsourceid><addsrcrecordid>eNqNUE1LAzEQzUHBWv0PexG8bE32I5steChFq1DxoueQnUzalP0y2S3svzelnjwVBmaYee_x5hHywOiCUcafDguHCgYztjD0XT01iySsF5SFYldkxlLB4pxl4obcen-glBWM8xlZfozQKb1Hb7t2Ga2i3nWN9bbdRaoPs4J9ZNtIu3EXaaztEd0U-ckP2NyRa6Nqj_d_fU6-X1--1m_x9nPzvl5tY8hpMsQF5gCVVgYSajgXhieFURkKllap0EXOTVqGc4pQ5CnqosyyqkANJavA0Dydk8ezbrDzM6IfZDAIWNeqxW70kokkz7gQSXkBlIqC8oTTAH0-Q8F13js0sne2UW6SjMpTpPIg_0UqT5FKykKxwN-c-RheP1p00oPFFlBbhzBI3dkLlX4B2OOMWA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1808706260</pqid></control><display><type>article</type><title>Mucoadhesion: A promising approach in drug delivery system</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Mansuri, Shakir ; Kesharwani, Prashant ; Jain, Keerti ; Tekade, Rakesh K. ; Jain, N.K.</creator><creatorcontrib>Mansuri, Shakir ; Kesharwani, Prashant ; Jain, Keerti ; Tekade, Rakesh K. ; Jain, N.K.</creatorcontrib><description>Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems.</description><identifier>ISSN: 1381-5148</identifier><identifier>DOI: 10.1016/j.reactfunctpolym.2016.01.011</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Bioadhesion ; Biomolecules ; Drug delivery ; Drug delivery systems ; Lectins ; Metabolism ; Mucoadhesion ; Oligonucleotides ; Polymer ; Polymers ; Proteins ; Routes of drug administration ; Strategy ; Two materials</subject><ispartof>Reactive & functional polymers, 2016-03, Vol.100, p.151-172</ispartof><rights>2016 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-7e5ccbdafc20f668f627fa4e813b38d756f39daf3ec753ed7944b7edc91bcf053</citedby><cites>FETCH-LOGICAL-c502t-7e5ccbdafc20f668f627fa4e813b38d756f39daf3ec753ed7944b7edc91bcf053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1381514816300104$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Mansuri, Shakir</creatorcontrib><creatorcontrib>Kesharwani, Prashant</creatorcontrib><creatorcontrib>Jain, Keerti</creatorcontrib><creatorcontrib>Tekade, Rakesh K.</creatorcontrib><creatorcontrib>Jain, N.K.</creatorcontrib><title>Mucoadhesion: A promising approach in drug delivery system</title><title>Reactive & functional polymers</title><description>Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems.</description><subject>Bioadhesion</subject><subject>Biomolecules</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Lectins</subject><subject>Metabolism</subject><subject>Mucoadhesion</subject><subject>Oligonucleotides</subject><subject>Polymer</subject><subject>Polymers</subject><subject>Proteins</subject><subject>Routes of drug administration</subject><subject>Strategy</subject><subject>Two materials</subject><issn>1381-5148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUE1LAzEQzUHBWv0PexG8bE32I5steChFq1DxoueQnUzalP0y2S3svzelnjwVBmaYee_x5hHywOiCUcafDguHCgYztjD0XT01iySsF5SFYldkxlLB4pxl4obcen-glBWM8xlZfozQKb1Hb7t2Ga2i3nWN9bbdRaoPs4J9ZNtIu3EXaaztEd0U-ckP2NyRa6Nqj_d_fU6-X1--1m_x9nPzvl5tY8hpMsQF5gCVVgYSajgXhieFURkKllap0EXOTVqGc4pQ5CnqosyyqkANJavA0Dydk8ezbrDzM6IfZDAIWNeqxW70kokkz7gQSXkBlIqC8oTTAH0-Q8F13js0sne2UW6SjMpTpPIg_0UqT5FKykKxwN-c-RheP1p00oPFFlBbhzBI3dkLlX4B2OOMWA</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Mansuri, Shakir</creator><creator>Kesharwani, Prashant</creator><creator>Jain, Keerti</creator><creator>Tekade, Rakesh K.</creator><creator>Jain, N.K.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>JG9</scope></search><sort><creationdate>20160301</creationdate><title>Mucoadhesion: A promising approach in drug delivery system</title><author>Mansuri, Shakir ; Kesharwani, Prashant ; Jain, Keerti ; Tekade, Rakesh K. ; Jain, N.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-7e5ccbdafc20f668f627fa4e813b38d756f39daf3ec753ed7944b7edc91bcf053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bioadhesion</topic><topic>Biomolecules</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Lectins</topic><topic>Metabolism</topic><topic>Mucoadhesion</topic><topic>Oligonucleotides</topic><topic>Polymer</topic><topic>Polymers</topic><topic>Proteins</topic><topic>Routes of drug administration</topic><topic>Strategy</topic><topic>Two materials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansuri, Shakir</creatorcontrib><creatorcontrib>Kesharwani, Prashant</creatorcontrib><creatorcontrib>Jain, Keerti</creatorcontrib><creatorcontrib>Tekade, Rakesh K.</creatorcontrib><creatorcontrib>Jain, N.K.</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Research Database</collection><jtitle>Reactive & functional polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansuri, Shakir</au><au>Kesharwani, Prashant</au><au>Jain, Keerti</au><au>Tekade, Rakesh K.</au><au>Jain, N.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucoadhesion: A promising approach in drug delivery system</atitle><jtitle>Reactive & functional polymers</jtitle><date>2016-03-01</date><risdate>2016</risdate><volume>100</volume><spage>151</spage><epage>172</epage><pages>151-172</pages><issn>1381-5148</issn><abstract>Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.reactfunctpolym.2016.01.011</doi><tpages>22</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1381-5148 |
| ispartof | Reactive & functional polymers, 2016-03, Vol.100, p.151-172 |
| issn | 1381-5148 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1825468829 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Bioadhesion Biomolecules Drug delivery Drug delivery systems Lectins Metabolism Mucoadhesion Oligonucleotides Polymer Polymers Proteins Routes of drug administration Strategy Two materials |
| title | Mucoadhesion: A promising approach in drug delivery system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T15%3A14%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mucoadhesion:%20A%20promising%20approach%20in%20drug%20delivery%20system&rft.jtitle=Reactive%20&%20functional%20polymers&rft.au=Mansuri,%20Shakir&rft.date=2016-03-01&rft.volume=100&rft.spage=151&rft.epage=172&rft.pages=151-172&rft.issn=1381-5148&rft_id=info:doi/10.1016/j.reactfunctpolym.2016.01.011&rft_dat=%3Cproquest_cross%3E1825468829%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1808706260&rft_id=info:pmid/&rft_els_id=S1381514816300104&rfr_iscdi=true |