Mannose metabolism in recombinant CHO cells and its effect on IgG glycosylation

ABSTRACT Understanding the causes of high‐mannose (HM) glycosylation of recombinant IgG in CHO cells would facilitate the production of therapeutics. CHO cells grown with mannose as the major carbon source demonstrated a dramatic increase in total HM glycosylation in recombinant IgG, with no effect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biotechnology and bioengineering 2016-07, Vol.113 (7), p.1468-1480
Hauptverfasser:	Slade, Peter G., Caspary, R. Guy, Nargund, Shilpa, Huang, Chung-Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioengineering Biotechnology Carbon Cellular biology CHO CHO Cells Cricetinae Cricetulus Flux flux analysis Glycosylation high-mannose IgG Immunoglobulin G - chemistry Immunoglobulin G - metabolism Mannose Mannose - metabolism Metabolic Flux Analysis Metabolism Pathways Productivity Recombinant Recombinant Proteins - chemistry Recombinant Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!