Ethyl-2-(3,5-Dihidroxyfenol): Phloroglucinol derivatives as potential anticancer material
Ethyl-2-(3,5-dihidroxyfenol) based phloroglucinol compounds have been synthesized. Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temp...
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| Veröffentlicht in: | IOP conference series. Materials Science and Engineering 2016-01, Vol.107 (1), p.12059-12067 |
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| container_title | IOP conference series. Materials Science and Engineering |
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| creator | Kusumaningsih, Triana Firdaus, Maulidan Wartono, Muhammad Widyo Artanti, Anif Nur Handayani, Desi Suci Putro, Angga Eryanto |
| description | Ethyl-2-(3,5-dihidroxyfenol) based phloroglucinol compounds have been synthesized. Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temperature of 56 oC. The reaction products were identified by a thin layer chromatography and were characterized by melting point test. Analysis of the structure of the products was obtained by FTIR spectrophotometer, H-NMR, and 13C-NMR. The result of the reaction between phloroglucinol and 2-chloro ethyl acetate was brownish black solid, and has a melting point of 191 oC. Based on the structural analysis by FTIR, 1H-NMR and 13C-NMR, the reaction product was a mixture of compounds which is ethyl 2- (3,5-dihidroksifenol) acetate, ethyl-2-(2,4,6-trioxocyclohexyl) acetate, and the rest of phloroglucinol which can not react. |
| doi_str_mv | 10.1088/1757-899X/107/1/012059 |
| format | Article |
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Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temperature of 56 oC. The reaction products were identified by a thin layer chromatography and were characterized by melting point test. Analysis of the structure of the products was obtained by FTIR spectrophotometer, H-NMR, and 13C-NMR. The result of the reaction between phloroglucinol and 2-chloro ethyl acetate was brownish black solid, and has a melting point of 191 oC. Based on the structural analysis by FTIR, 1H-NMR and 13C-NMR, the reaction product was a mixture of compounds which is ethyl 2- (3,5-dihidroksifenol) acetate, ethyl-2-(2,4,6-trioxocyclohexyl) acetate, and the rest of phloroglucinol which can not react.</description><identifier>ISSN: 1757-8981</identifier><identifier>EISSN: 1757-899X</identifier><identifier>DOI: 10.1088/1757-899X/107/1/012059</identifier><language>eng</language><publisher>Bristol: IOP Publishing</publisher><subject>Acetates ; Derivatives ; Ethyl acetate ; Melting points ; NMR ; Nuclear magnetic resonance ; Phloroglucinol ; Reaction products ; Rest ; Structural analysis ; Thin layer chromatography</subject><ispartof>IOP conference series. Materials Science and Engineering, 2016-01, Vol.107 (1), p.12059-12067</ispartof><rights>Published under licence by IOP Publishing Ltd</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Materials Science and Engineering</title><addtitle>IOP Conf. Ser.: Mater. Sci. Eng</addtitle><description>Ethyl-2-(3,5-dihidroxyfenol) based phloroglucinol compounds have been synthesized. Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temperature of 56 oC. The reaction products were identified by a thin layer chromatography and were characterized by melting point test. Analysis of the structure of the products was obtained by FTIR spectrophotometer, H-NMR, and 13C-NMR. The result of the reaction between phloroglucinol and 2-chloro ethyl acetate was brownish black solid, and has a melting point of 191 oC. Based on the structural analysis by FTIR, 1H-NMR and 13C-NMR, the reaction product was a mixture of compounds which is ethyl 2- (3,5-dihidroksifenol) acetate, ethyl-2-(2,4,6-trioxocyclohexyl) acetate, and the rest of phloroglucinol which can not react.</description><subject>Acetates</subject><subject>Derivatives</subject><subject>Ethyl acetate</subject><subject>Melting points</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phloroglucinol</subject><subject>Reaction products</subject><subject>Rest</subject><subject>Structural analysis</subject><subject>Thin layer chromatography</subject><issn>1757-8981</issn><issn>1757-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkEtLxDAUhYsoOI7-BSm4UbA2adMkdSfj-IABXSjoKqR5OBkyTU3awfn3tlRGcOPqvr5zuJwoOoXgCgJKU0gKktCyfEshIClMAcxAUe5Fk91hf9dTeBgdhbACABOEwCR6n7fLrU2y5Dy_LJJbszTSu6-tVrWzF9fx89I67z5sJ0y_iKXyZsNbs1Eh5iFuXKvq1nAb874IXgvl4zVve4rb4-hAcxvUyU-dRq9385fZQ7J4un-c3SwSgRBqk0ojqjVFBJcSI0wRyrjOJZQay5zkskK6LIclEViVlZAVREJCAFSls1yKfBqdj76Nd5-dCi1bmyCUtbxWrgsM0qxABcAF7dGzP-jKdb7uv2NZgQtAASFZT-GREt6F4JVmjTdr7rcMAjYkzoYw2RBsPxIG2Zh4L8xGoXHNr_M_om9W54NU</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kusumaningsih, Triana</creator><creator>Firdaus, Maulidan</creator><creator>Wartono, Muhammad Widyo</creator><creator>Artanti, Anif Nur</creator><creator>Handayani, Desi Suci</creator><creator>Putro, Angga Eryanto</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>20160101</creationdate><title>Ethyl-2-(3,5-Dihidroxyfenol): Phloroglucinol derivatives as potential anticancer material</title><author>Kusumaningsih, Triana ; 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Ethyl-2-(3,5-dihidroksifenol) were synthesized by reacting phloroglucinol with ethyl 2-chloro acetate in excess. Phloroglucinol reaction using 2-chloro ethyl acetate was carried out under reflux for 24 hours at a temperature of 56 oC. The reaction products were identified by a thin layer chromatography and were characterized by melting point test. Analysis of the structure of the products was obtained by FTIR spectrophotometer, H-NMR, and 13C-NMR. The result of the reaction between phloroglucinol and 2-chloro ethyl acetate was brownish black solid, and has a melting point of 191 oC. Based on the structural analysis by FTIR, 1H-NMR and 13C-NMR, the reaction product was a mixture of compounds which is ethyl 2- (3,5-dihidroksifenol) acetate, ethyl-2-(2,4,6-trioxocyclohexyl) acetate, and the rest of phloroglucinol which can not react.</abstract><cop>Bristol</cop><pub>IOP Publishing</pub><doi>10.1088/1757-899X/107/1/012059</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetates Derivatives Ethyl acetate Melting points NMR Nuclear magnetic resonance Phloroglucinol Reaction products Rest Structural analysis Thin layer chromatography |
| title | Ethyl-2-(3,5-Dihidroxyfenol): Phloroglucinol derivatives as potential anticancer material |
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