Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties

Among diabetic cardiovascular complications cardiomyopathy is major event which if not well controlled culminates in cardiac failure. Wogonin from the root of Scutellaria baicalensis Georgi has shown specific anti-diabetes bioactivity. However, its effect on diabetic complications remains unclear. T...

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Veröffentlicht in:	Molecular and cellular endocrinology 2016-06, Vol.428, p.101-108
Hauptverfasser:	Khan, Shahzad, Zhang, Deling, Zhang, Yemin, Li, Mingxin, Wang, Changhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Attenuation Biochemistry Blood Glucose - metabolism Diabetic Cardiomyopathies - complications Diabetic Cardiomyopathies - diagnostic imaging Diabetic Cardiomyopathies - drug therapy Diabetic Cardiomyopathies - physiopathology Diabetic cardiomyopathy Endocrinology Fibrosis Flavanones Heart Function Tests Hyperglycemia Hyperglycemia - blood Hyperglycemia - complications Hyperglycemia - drug therapy Impairment Inflammation Inflammation - pathology Male Mice Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Organ Size - drug effects Oxidative stress Oxidative Stress - drug effects Rats, Sprague-Dawley Roots Stresses Wogonin
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