Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells

Successful fertilization depends upon proper cumulus–oocyte complex (COC) expansion. Synthesized by hyaluronan synthases (HASs), hyaluronan forms the backbone of the COC matrix and plays a critical role in COC expansion. This study investigated the effects and mechanisms of ovarian BMPs on HAS expre...

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Veröffentlicht in:	Molecular and cellular endocrinology 2016-06, Vol.428, p.17-27
Hauptverfasser:	Zhang, Han, Tian, Shen, Klausen, Christian, Zhu, Hua, Liu, Ruizhi, Leung, Peter C.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Blocking BMP Bone Morphogenetic Protein Receptors, Type I - metabolism Bone Morphogenetic Proteins - pharmacology Bones Cells, Cultured Female Fertilization Glucuronosyltransferase - metabolism Granulosa Cells - drug effects Granulosa Cells - metabolism HAS2 Human Human granulosa cell Humans Hyaluronan Hyaluronan Synthases Hyaluronic Acid - biosynthesis Luteal Cells - drug effects Luteal Cells - metabolism Phosphorylation Phosphorylation - drug effects Protein-Serine-Threonine Kinases - metabolism Receptors Receptors, Transforming Growth Factor beta - metabolism Signal Transduction - drug effects SMAD1/5/8 SMAD2 Smad2 Protein - metabolism SMAD3 Smad3 Protein - metabolism Up-Regulation - drug effects
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