Use of fusion protein constructs to generate potent immunotherapy and protection against scorpion toxins

We report the use of recombinant scorpion toxins in the form of fusion proteins as antigens for immunisation in rabbits and mice: the aim was to produce in these animal models protective antisera against the most lethal α-type toxins in the venom from the North African scorpion Androctonus australis...

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Veröffentlicht in:	Vaccine 2001-12, Vol.20 (5), p.934-942
Hauptverfasser:	Legros, Christian, Kaabi, Hajer, El Ayeb, Mohammed, Céard, Brigitte, Vacher, Hélène, Bougis, Pierre E, Martin-Eauclaire, Marie-France
Format:	Artikel
Sprache:	eng
Schlagworte:	AaH I protein AaH II protein AaH III protein Androctonus australis Animals Antibodies Bacteriology Base Sequence Biological and medical sciences Buthidae DNA, Complementary - genetics Epidemiology. Vaccinations Escherichia coli Fundamental and applied biological sciences. Psychology General aspects Humans Immunization Immunotherapy Immunotherapy - methods Infectious diseases Medical sciences Mice Microbiology Neuropeptides - antagonists & inhibitors Neuropeptides - genetics Neuropeptides - immunology Neuropeptides - toxicity Neurotoxins - antagonists & inhibitors Neurotoxins - genetics Neurotoxins - immunology Neurotoxins - toxicity Neutralization Tests Plasmids - genetics Rabbits Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Reptilian Proteins Scorpion Scorpion Venoms - antagonists & inhibitors Scorpion Venoms - genetics Scorpion Venoms - immunology Scorpion Venoms - toxicity Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology
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