Role of Candida in Antibiotic-Associated Diarrhea
To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A+D−), 97...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2001-10, Vol.184 (8), p.1065-1069 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1069 |
|---|---|
| container_issue | 8 |
| container_start_page | 1065 |
| container_title | The Journal of infectious diseases |
| container_volume | 184 |
| creator | Krause, Robert Schwab, Egon Bachhiesl, Daniela Daxböck, Florian Wenisch, Christoph Krejs, Günter J. Reisinger, Emil C. |
| description | To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A+D−), 97 patients were not taking antibiotics but had diarrhea (A−D+), and 107 patients were control subjects (A−D−). In addition, secreted aspartyl proteinase (Sap) production was tested. In AAD patients, Candida positivity (77/98) and Candida overgrowth (62/98) were not different from that among A+D− patients (75/93 [P=.860] and 52/93 [P=.375], respectively). Candida overgrowth among A−D+ patients (40/97, P=.003) was less frequent than among AAD patients, but Candida positivity was not different (80/97, P=.612). In control subjects, Candida positivity and overgrowth were less common than in all other groups. Production of Sap did not differ between patients with AAD and control subjects (P=.568 and P=.590, respectively). Data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea rather than a cause of AAD |
| doi_str_mv | 10.1086/323550 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_18252980</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30137662</jstor_id><oup_id>10.1086/323550</oup_id><sourcerecordid>30137662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-c2b32c69a9db7e4e24306d17477a12e68272e5efc9457b05076651a5f29e86c63</originalsourceid><addsrcrecordid>eNp10F1LHDEYBeAgFV21_QeVqaB3Y5M3X5PLZf1YZbGltFS8CZlMBrOdnWyTGdB_36mzuCB4lYvzcN5wEPpE8DnBhfhKgXKOd9CEcCpzIQj9gCYYA-SkUGofHaS0xBgzKuQe2ieES6aAThD5ERqXhTqbmbbylcl8m03bzpc-dN7m05SC9aZzVXbhTYyPzhyh3do0yX3cvIfo19Xlz9k8X3y7vplNF7llBelyCyUFK5RRVSkdc8AoFhWRTEpDwIkCJDjuaqsYlyXmWArBieE1KFcIK-ghOht71zH87V3q9Mon65rGtC70SZMCOKgCD_DkDVyGPrbD3zQAVZgWjG3bbAwpRVfrdfQrE581wfr_gnpccIDHm7a-XLlqyzaTDeB0A0yypqmjaa1PW8cIF_LFfRld6NfvH_s8mmXqQnxVFBM6zAFDno-5T517es1N_KOFpJLr-f2Dnn-_-D2_W9xqoP8AbjeWig</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223903844</pqid></control><display><type>article</type><title>Role of Candida in Antibiotic-Associated Diarrhea</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Krause, Robert ; Schwab, Egon ; Bachhiesl, Daniela ; Daxböck, Florian ; Wenisch, Christoph ; Krejs, Günter J. ; Reisinger, Emil C.</creator><creatorcontrib>Krause, Robert ; Schwab, Egon ; Bachhiesl, Daniela ; Daxböck, Florian ; Wenisch, Christoph ; Krejs, Günter J. ; Reisinger, Emil C.</creatorcontrib><description>To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A+D−), 97 patients were not taking antibiotics but had diarrhea (A−D+), and 107 patients were control subjects (A−D−). In addition, secreted aspartyl proteinase (Sap) production was tested. In AAD patients, Candida positivity (77/98) and Candida overgrowth (62/98) were not different from that among A+D− patients (75/93 [P=.860] and 52/93 [P=.375], respectively). Candida overgrowth among A−D+ patients (40/97, P=.003) was less frequent than among AAD patients, but Candida positivity was not different (80/97, P=.612). In control subjects, Candida positivity and overgrowth were less common than in all other groups. Production of Sap did not differ between patients with AAD and control subjects (P=.568 and P=.590, respectively). Data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea rather than a cause of AAD</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/323550</identifier><identifier>PMID: 11574923</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Age Distribution ; Anti-Bacterial Agents - adverse effects ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; aspartyl proteinase ; Biological and medical sciences ; Candida ; Candida - classification ; Candida - growth & development ; Candida - isolation & purification ; Candida albicans ; Diarrhea ; Diarrhea - chemically induced ; Diarrhea - drug therapy ; Feces - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Major Article ; Male ; Medical sciences ; Microbiology ; Mucins ; Mycology ; Pathogenicity, host-agent relations, miscellaneous strains, epidemiology ; Patient Selection ; Pharmacology. Drug treatments ; Reference Values ; Secretion ; Vaginitis ; Virulence ; Virulence factors ; Yeasts</subject><ispartof>The Journal of infectious diseases, 2001-10, Vol.184 (8), p.1065-1069</ispartof><rights>Copyright 2001 Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 15, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-c2b32c69a9db7e4e24306d17477a12e68272e5efc9457b05076651a5f29e86c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137662$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137662$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14156723$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11574923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krause, Robert</creatorcontrib><creatorcontrib>Schwab, Egon</creatorcontrib><creatorcontrib>Bachhiesl, Daniela</creatorcontrib><creatorcontrib>Daxböck, Florian</creatorcontrib><creatorcontrib>Wenisch, Christoph</creatorcontrib><creatorcontrib>Krejs, Günter J.</creatorcontrib><creatorcontrib>Reisinger, Emil C.</creatorcontrib><title>Role of Candida in Antibiotic-Associated Diarrhea</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A+D−), 97 patients were not taking antibiotics but had diarrhea (A−D+), and 107 patients were control subjects (A−D−). In addition, secreted aspartyl proteinase (Sap) production was tested. In AAD patients, Candida positivity (77/98) and Candida overgrowth (62/98) were not different from that among A+D− patients (75/93 [P=.860] and 52/93 [P=.375], respectively). Candida overgrowth among A−D+ patients (40/97, P=.003) was less frequent than among AAD patients, but Candida positivity was not different (80/97, P=.612). In control subjects, Candida positivity and overgrowth were less common than in all other groups. Production of Sap did not differ between patients with AAD and control subjects (P=.568 and P=.590, respectively). Data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea rather than a cause of AAD</description><subject>Age Distribution</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>aspartyl proteinase</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candida - classification</subject><subject>Candida - growth & development</subject><subject>Candida - isolation & purification</subject><subject>Candida albicans</subject><subject>Diarrhea</subject><subject>Diarrhea - chemically induced</subject><subject>Diarrhea - drug therapy</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Major Article</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mucins</subject><subject>Mycology</subject><subject>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</subject><subject>Patient Selection</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>Secretion</subject><subject>Vaginitis</subject><subject>Virulence</subject><subject>Virulence factors</subject><subject>Yeasts</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1LHDEYBeAgFV21_QeVqaB3Y5M3X5PLZf1YZbGltFS8CZlMBrOdnWyTGdB_36mzuCB4lYvzcN5wEPpE8DnBhfhKgXKOd9CEcCpzIQj9gCYYA-SkUGofHaS0xBgzKuQe2ieES6aAThD5ERqXhTqbmbbylcl8m03bzpc-dN7m05SC9aZzVXbhTYyPzhyh3do0yX3cvIfo19Xlz9k8X3y7vplNF7llBelyCyUFK5RRVSkdc8AoFhWRTEpDwIkCJDjuaqsYlyXmWArBieE1KFcIK-ghOht71zH87V3q9Mon65rGtC70SZMCOKgCD_DkDVyGPrbD3zQAVZgWjG3bbAwpRVfrdfQrE581wfr_gnpccIDHm7a-XLlqyzaTDeB0A0yypqmjaa1PW8cIF_LFfRld6NfvH_s8mmXqQnxVFBM6zAFDno-5T517es1N_KOFpJLr-f2Dnn-_-D2_W9xqoP8AbjeWig</recordid><startdate>20011015</startdate><enddate>20011015</enddate><creator>Krause, Robert</creator><creator>Schwab, Egon</creator><creator>Bachhiesl, Daniela</creator><creator>Daxböck, Florian</creator><creator>Wenisch, Christoph</creator><creator>Krejs, Günter J.</creator><creator>Reisinger, Emil C.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>M7N</scope></search><sort><creationdate>20011015</creationdate><title>Role of Candida in Antibiotic-Associated Diarrhea</title><author>Krause, Robert ; Schwab, Egon ; Bachhiesl, Daniela ; Daxböck, Florian ; Wenisch, Christoph ; Krejs, Günter J. ; Reisinger, Emil C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-c2b32c69a9db7e4e24306d17477a12e68272e5efc9457b05076651a5f29e86c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Distribution</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>aspartyl proteinase</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candida - classification</topic><topic>Candida - growth & development</topic><topic>Candida - isolation & purification</topic><topic>Candida albicans</topic><topic>Diarrhea</topic><topic>Diarrhea - chemically induced</topic><topic>Diarrhea - drug therapy</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Major Article</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Mucins</topic><topic>Mycology</topic><topic>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</topic><topic>Patient Selection</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Values</topic><topic>Secretion</topic><topic>Vaginitis</topic><topic>Virulence</topic><topic>Virulence factors</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krause, Robert</creatorcontrib><creatorcontrib>Schwab, Egon</creatorcontrib><creatorcontrib>Bachhiesl, Daniela</creatorcontrib><creatorcontrib>Daxböck, Florian</creatorcontrib><creatorcontrib>Wenisch, Christoph</creatorcontrib><creatorcontrib>Krejs, Günter J.</creatorcontrib><creatorcontrib>Reisinger, Emil C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krause, Robert</au><au>Schwab, Egon</au><au>Bachhiesl, Daniela</au><au>Daxböck, Florian</au><au>Wenisch, Christoph</au><au>Krejs, Günter J.</au><au>Reisinger, Emil C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Candida in Antibiotic-Associated Diarrhea</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2001-10-15</date><risdate>2001</risdate><volume>184</volume><issue>8</issue><spage>1065</spage><epage>1069</epage><pages>1065-1069</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To quantitatively assess the role of Candida species in antibiotic-associated diarrhea (AAD), stool samples from a total of 395 patients and control subjects were cultured in differential isolation medium: 98 patients had AAD, 93 patients were taking antibiotics but did not have diarrhea (A+D−), 97 patients were not taking antibiotics but had diarrhea (A−D+), and 107 patients were control subjects (A−D−). In addition, secreted aspartyl proteinase (Sap) production was tested. In AAD patients, Candida positivity (77/98) and Candida overgrowth (62/98) were not different from that among A+D− patients (75/93 [P=.860] and 52/93 [P=.375], respectively). Candida overgrowth among A−D+ patients (40/97, P=.003) was less frequent than among AAD patients, but Candida positivity was not different (80/97, P=.612). In control subjects, Candida positivity and overgrowth were less common than in all other groups. Production of Sap did not differ between patients with AAD and control subjects (P=.568 and P=.590, respectively). Data indicate that elevated Candida counts are a result of antibiotic treatment or diarrhea rather than a cause of AAD</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11574923</pmid><doi>10.1086/323550</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2001-10, Vol.184 (8), p.1065-1069 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18252980 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Age Distribution Anti-Bacterial Agents - adverse effects Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents aspartyl proteinase Biological and medical sciences Candida Candida - classification Candida - growth & development Candida - isolation & purification Candida albicans Diarrhea Diarrhea - chemically induced Diarrhea - drug therapy Feces - microbiology Female Fundamental and applied biological sciences. Psychology Humans Major Article Male Medical sciences Microbiology Mucins Mycology Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Patient Selection Pharmacology. Drug treatments Reference Values Secretion Vaginitis Virulence Virulence factors Yeasts |
| title | Role of Candida in Antibiotic-Associated Diarrhea |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T22%3A42%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Candida%20in%20Antibiotic-Associated%20Diarrhea&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Krause,%20Robert&rft.date=2001-10-15&rft.volume=184&rft.issue=8&rft.spage=1065&rft.epage=1069&rft.pages=1065-1069&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/323550&rft_dat=%3Cjstor_proqu%3E30137662%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223903844&rft_id=info:pmid/11574923&rft_jstor_id=30137662&rft_oup_id=10.1086/323550&rfr_iscdi=true |