Shear stress regulates endothelial cell function through SRB1‐eNOS signaling pathway

Summary Aim The aim of this study was to explore whether transmembrane flow shear stress could regulate eNOS expression and mediate endothelial cell function via SR‐B1 signaling transduction. Methods Parallel‐plate flow chamber was used to impose laminar shear stress and evaluate the effect of shear...

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Veröffentlicht in:	Cardiovascular therapeutics 2016-10, Vol.34 (5), p.308-313
Hauptverfasser:	Zhang, Ying, Liao, Bin, Li, Miaoling, Cheng, Min, Fu, Yong, Liu, Qing, Chen, Qi, Liu, Hongduan, Fang, Yibing, Zhang, Gen, Yu, Fengxu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured endothelial cell eNOS Gene Expression Regulation, Enzymologic Human Umbilical Vein Endothelial Cells Humans mechanosensor Mechanotransduction, Cellular Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism RNA Interference Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism shear stress SR‐B1 Stress, Mechanical Time Factors Transfection
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