For Immunoglobulin Light Chains, It's Time to Fly
[...]there were discrepancies when their MS results were compared with IFE. Because the authors did not have access to detailed clinical information about these patients, the significance of these discrepancies is unclear. Using the mass spectra of isolated heavy chains is challenging due to variabl...
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| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2016-10, Vol.62 (10), p.1293-1295 |
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| creator | Faix, James D |
| description | [...]there were discrepancies when their MS results were compared with IFE. Because the authors did not have access to detailed clinical information about these patients, the significance of these discrepancies is unclear. Using the mass spectra of isolated heavy chains is challenging due to variable glycosylation as well as poor ionization relative to the light chains. Because the spectra of the normal polyclonal background may overlap small peaks using MS, some of the problems that currently plague M-component quantification when this occurs using SPE or CZE may still be a problem. |
| doi_str_mv | 10.1373/clinchem.2016.261933 |
| format | Article |
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Because the authors did not have access to detailed clinical information about these patients, the significance of these discrepancies is unclear. Using the mass spectra of isolated heavy chains is challenging due to variable glycosylation as well as poor ionization relative to the light chains. Because the spectra of the normal polyclonal background may overlap small peaks using MS, some of the problems that currently plague M-component quantification when this occurs using SPE or CZE may still be a problem.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2016.261933</identifier><identifier>PMID: 27509910</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Chemical bonds ; Diagnostic Tests, Routine ; Fish ; Immunoglobulin Light Chains ; Immunoglobulins ; Ionization ; Ions ; Laboratories ; Light ; Mass spectra ; Medical research ; Multiple myeloma ; Patients ; Proteins ; Studies</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2016-10, Vol.62 (10), p.1293-1295</ispartof><rights>Copyright American Association for Clinical Chemistry Oct 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c330t-f9123ea0e1e06f5e928fe217158c28a669f00e6f31a8f9636c81137ebc905dfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27509910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faix, James D</creatorcontrib><title>For Immunoglobulin Light Chains, It's Time to Fly</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>[...]there were discrepancies when their MS results were compared with IFE. Because the authors did not have access to detailed clinical information about these patients, the significance of these discrepancies is unclear. Using the mass spectra of isolated heavy chains is challenging due to variable glycosylation as well as poor ionization relative to the light chains. Because the spectra of the normal polyclonal background may overlap small peaks using MS, some of the problems that currently plague M-component quantification when this occurs using SPE or CZE may still be a problem.</description><subject>Chemical bonds</subject><subject>Diagnostic Tests, Routine</subject><subject>Fish</subject><subject>Immunoglobulin Light Chains</subject><subject>Immunoglobulins</subject><subject>Ionization</subject><subject>Ions</subject><subject>Laboratories</subject><subject>Light</subject><subject>Mass spectra</subject><subject>Medical research</subject><subject>Multiple 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| ispartof | Clinical chemistry (Baltimore, Md.), 2016-10, Vol.62 (10), p.1293-1295 |
| issn | 0009-9147 1530-8561 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Chemical bonds Diagnostic Tests, Routine Fish Immunoglobulin Light Chains Immunoglobulins Ionization Ions Laboratories Light Mass spectra Medical research Multiple myeloma Patients Proteins Studies |
| title | For Immunoglobulin Light Chains, It's Time to Fly |
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