IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo

We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The induction of these cytokines resulted in Th2-like responses marked by increased serum IgE, IgG 1, and IgA levels, blood eosinophilia, and pathol...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2001-12, Vol.15 (6), p.985-995
Hauptverfasser:	Fort, Madeline M., Cheung, Jeanne, Yen, David, Li, Joana, Zurawski, Sandra M., Lo, Sylvia, Menon, Satish, Clifford, Teresa, Hunte, Brisdell, Lesley, Robin, Muchamuel, Tony, Hurst, Stephen D., Zurawski, Gerard, Leach, Michael W., Gorman, Daniel M., Rennick, Donna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Lineage Cells, Cultured Cloning, Molecular DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Eosinophilia - chemically induced Eosinophilia - immunology Eosinophilia - pathology Gastric Mucosa - pathology Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - immunology Gastrointestinal Diseases - pathology Gene Expression Regulation - drug effects Growth Substances - isolation & purification Growth Substances - pharmacology Growth Substances - secretion Growth Substances - toxicity Histocompatibility Antigens Class II - analysis Humans Hypergammaglobulinemia - chemically induced Hyperplasia Hypertrophy Integrin alphaXbeta2 - analysis interleukin 25 Interleukin-13 - biosynthesis Interleukin-13 - genetics Interleukin-17 Interleukin-4 - biosynthesis Interleukin-4 - genetics Interleukin-5 - biosynthesis Interleukin-5 - genetics Interleukins Intestinal Mucosa - pathology Lung - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Nuclear Proteins Pulmonary Eosinophilia - chemically induced Pulmonary Eosinophilia - immunology Pulmonary Eosinophilia - pathology Receptors, Interleukin-4 - deficiency Receptors, Interleukin-4 - genetics RNA, Messenger - biosynthesis Sequence Alignment Sequence Homology, Amino Acid T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - secretion Th2 Cells - chemistry Th2 Cells - secretion
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