Effect of the presence of trophectoderm vesicles on blastocyst in relation to in vitro hatching, clinical pregnancy, and miscarriage rates
Trophectoderm vesicles (TVs) are observed in some blastocysts that penetrate cells from the zona pellucida to the outer margin. Therefore, we compared this incidence in relation to hatching, pregnancy, and miscarriage rates between conventional in vitro fertilization (c-IVF) and intracytoplasmic spe...
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| Veröffentlicht in: | Human cell : official journal of Human Cell Research Society 2016-10, Vol.29 (4), p.176-180 |
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| creator | Araki, Yasuhisa Matsui, Yuki Iizumi, Ayaka Tsuchiya, Syoutarou Kaneko, Yumi Sato, Kazufumi Ozaki, Tomoya Araki, Yasuyuki Nishimura, Mitsuru |
| description | Trophectoderm vesicles (TVs) are observed in some blastocysts that penetrate cells from the zona pellucida to the outer margin. Therefore, we compared this incidence in relation to hatching, pregnancy, and miscarriage rates between conventional in vitro fertilization (c-IVF) and intracytoplasmic sperm injection (ICSI). Vitrified/warmed blastocysts (
n
= 112) were derived from surplus embryos. The blastocysts were then observed using time-lapse cinematography to resolve the relationship between hatching and implantation. Another study was conducted that comprised 681 embryo transfer cycles in 533 patients who received a single vitrified/warmed blastocyst from our clinic. The incidence of TV was significantly higher in embryos inseminated by ICSI compared with c-IVF [ICSI: 51/56 (91 %); c-IVF: 25/56 (45 %);
P
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| doi_str_mv | 10.1007/s13577-016-0141-y |
| format | Article |
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n
= 112) were derived from surplus embryos. The blastocysts were then observed using time-lapse cinematography to resolve the relationship between hatching and implantation. Another study was conducted that comprised 681 embryo transfer cycles in 533 patients who received a single vitrified/warmed blastocyst from our clinic. The incidence of TV was significantly higher in embryos inseminated by ICSI compared with c-IVF [ICSI: 51/56 (91 %); c-IVF: 25/56 (45 %);
P
< 0.01]. The successful hatching rate was significantly lower in ICSI than in c-IVF [ICSI: 11/56 (20 %); c-IVF: 29/56 (52 %);
P
< 0.01]. In addition, the hatching rate was significantly lower when TVs were present (14/76; 18 %) than in non-TV embryos (26/36; 72 %) (
P
< 0.01). In regard to the clinical study results, no significant differences were found between the groups in the pregnancy rate (TV present group: 107/183, 58.5 %; TV absent group: 273/498, 54.8 %) and miscarriage rate (TV present group: 21/107, 19.6 %; TV absent group: 53/273, 19.4 %). In vivo, we hypothesized that hatching and hatched would occur naturally by assisting protease action in the uterus; therefore, these results suggest that the presence of TV has no effect on pregnancy rates in the clinical setting.</description><identifier>ISSN: 1749-0774</identifier><identifier>ISSN: 0914-7470</identifier><identifier>EISSN: 1749-0774</identifier><identifier>DOI: 10.1007/s13577-016-0141-y</identifier><identifier>PMID: 27277221</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abortion, Spontaneous ; Adult ; Biomedical and Life Sciences ; Blastocyst - cytology ; Blastocyst - physiology ; Blastocysts ; Cell Biology ; Cinematography ; Embryo Implantation ; Embryo Transfer ; Female ; Fertility ; Fertilization in Vitro ; Gynecology ; Hatching ; Humans ; Implantation ; In vitro fertilization ; Life Sciences ; Oncology ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Research Article ; Sperm Injections, Intracytoplasmic ; Stem Cells ; Surgery ; Trophectoderm ; Uterus ; Vesicles ; Zona Pellucida</subject><ispartof>Human cell : official journal of Human Cell Research Society, 2016-10, Vol.29 (4), p.176-180</ispartof><rights>Japan Human Cell Society and Springer Japan 2016</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-79e83464911e3e0934643fad2f9ce08b4a4ffcbd9015797218072dce861b1f7c3</citedby><cites>FETCH-LOGICAL-c396t-79e83464911e3e0934643fad2f9ce08b4a4ffcbd9015797218072dce861b1f7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13577-016-0141-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13577-016-0141-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27277221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araki, Yasuhisa</creatorcontrib><creatorcontrib>Matsui, Yuki</creatorcontrib><creatorcontrib>Iizumi, Ayaka</creatorcontrib><creatorcontrib>Tsuchiya, Syoutarou</creatorcontrib><creatorcontrib>Kaneko, Yumi</creatorcontrib><creatorcontrib>Sato, Kazufumi</creatorcontrib><creatorcontrib>Ozaki, Tomoya</creatorcontrib><creatorcontrib>Araki, Yasuyuki</creatorcontrib><creatorcontrib>Nishimura, Mitsuru</creatorcontrib><title>Effect of the presence of trophectoderm vesicles on blastocyst in relation to in vitro hatching, clinical pregnancy, and miscarriage rates</title><title>Human cell : official journal of Human Cell Research Society</title><addtitle>Human Cell</addtitle><addtitle>Hum Cell</addtitle><description>Trophectoderm vesicles (TVs) are observed in some blastocysts that penetrate cells from the zona pellucida to the outer margin. Therefore, we compared this incidence in relation to hatching, pregnancy, and miscarriage rates between conventional in vitro fertilization (c-IVF) and intracytoplasmic sperm injection (ICSI). Vitrified/warmed blastocysts (
n
= 112) were derived from surplus embryos. The blastocysts were then observed using time-lapse cinematography to resolve the relationship between hatching and implantation. Another study was conducted that comprised 681 embryo transfer cycles in 533 patients who received a single vitrified/warmed blastocyst from our clinic. The incidence of TV was significantly higher in embryos inseminated by ICSI compared with c-IVF [ICSI: 51/56 (91 %); c-IVF: 25/56 (45 %);
P
< 0.01]. The successful hatching rate was significantly lower in ICSI than in c-IVF [ICSI: 11/56 (20 %); c-IVF: 29/56 (52 %);
P
< 0.01]. In addition, the hatching rate was significantly lower when TVs were present (14/76; 18 %) than in non-TV embryos (26/36; 72 %) (
P
< 0.01). In regard to the clinical study results, no significant differences were found between the groups in the pregnancy rate (TV present group: 107/183, 58.5 %; TV absent group: 273/498, 54.8 %) and miscarriage rate (TV present group: 21/107, 19.6 %; TV absent group: 53/273, 19.4 %). In vivo, we hypothesized that hatching and hatched would occur naturally by assisting protease action in the uterus; therefore, these results suggest that the presence of TV has no effect on pregnancy rates in the clinical setting.</description><subject>Abortion, Spontaneous</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Blastocyst - cytology</subject><subject>Blastocyst - physiology</subject><subject>Blastocysts</subject><subject>Cell Biology</subject><subject>Cinematography</subject><subject>Embryo Implantation</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertilization in Vitro</subject><subject>Gynecology</subject><subject>Hatching</subject><subject>Humans</subject><subject>Implantation</subject><subject>In vitro fertilization</subject><subject>Life Sciences</subject><subject>Oncology</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Research Article</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Stem Cells</subject><subject>Surgery</subject><subject>Trophectoderm</subject><subject>Uterus</subject><subject>Vesicles</subject><subject>Zona Pellucida</subject><issn>1749-0774</issn><issn>0914-7470</issn><issn>1749-0774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFO3DAQhq0KVCjtA_RSWeLSAwGP48TJESHaIiH1AmfLcca7Rll7sb1IeQWeug5LK4TUg-UZz_f_Hukn5Cuwc2BMXiSoGykrBm05Aqr5AzkGKfqKSSkO3tRH5FNKD4yJRrT8IznikkvJORyT52tr0WQaLM1rpNuICb3Blz6G7brMwohxQ58wOTNhosHTYdIpBzOnTJ2nESedXXnOYWmfXBHStc5m7fzqjJrJeWf0tHivvPZmPqPaj3TjktExOr1CGnXG9JkcWj0l_PJ6n5D7H9d3V7-q298_b64ubytT922uZI9dLVrRA2CNrF_q2uqR294g6wahhbVmGHsGjewlh45JPhrsWhjASlOfkO97320MjztMWS2r4DRpj2GXFHS84SABREFP36EPYRd92a5QHevaumFtoWBPmRhSimjVNrqNjrMCppag1D4oVYJSS1BqLppvr867YYPjP8XfZArA90AqI7_C-Obr_7r-Ae7Pn-A</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Araki, Yasuhisa</creator><creator>Matsui, Yuki</creator><creator>Iizumi, Ayaka</creator><creator>Tsuchiya, Syoutarou</creator><creator>Kaneko, Yumi</creator><creator>Sato, Kazufumi</creator><creator>Ozaki, Tomoya</creator><creator>Araki, Yasuyuki</creator><creator>Nishimura, Mitsuru</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Effect of the presence of trophectoderm vesicles on blastocyst in relation to in vitro hatching, clinical pregnancy, and miscarriage rates</title><author>Araki, Yasuhisa ; Matsui, Yuki ; Iizumi, Ayaka ; Tsuchiya, Syoutarou ; Kaneko, Yumi ; Sato, Kazufumi ; Ozaki, Tomoya ; Araki, Yasuyuki ; Nishimura, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-79e83464911e3e0934643fad2f9ce08b4a4ffcbd9015797218072dce861b1f7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abortion, Spontaneous</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Blastocyst - cytology</topic><topic>Blastocyst - physiology</topic><topic>Blastocysts</topic><topic>Cell Biology</topic><topic>Cinematography</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertilization in Vitro</topic><topic>Gynecology</topic><topic>Hatching</topic><topic>Humans</topic><topic>Implantation</topic><topic>In vitro fertilization</topic><topic>Life Sciences</topic><topic>Oncology</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Research Article</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Stem Cells</topic><topic>Surgery</topic><topic>Trophectoderm</topic><topic>Uterus</topic><topic>Vesicles</topic><topic>Zona Pellucida</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araki, Yasuhisa</creatorcontrib><creatorcontrib>Matsui, Yuki</creatorcontrib><creatorcontrib>Iizumi, Ayaka</creatorcontrib><creatorcontrib>Tsuchiya, Syoutarou</creatorcontrib><creatorcontrib>Kaneko, Yumi</creatorcontrib><creatorcontrib>Sato, Kazufumi</creatorcontrib><creatorcontrib>Ozaki, Tomoya</creatorcontrib><creatorcontrib>Araki, Yasuyuki</creatorcontrib><creatorcontrib>Nishimura, Mitsuru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human cell : official journal of Human Cell Research Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araki, Yasuhisa</au><au>Matsui, Yuki</au><au>Iizumi, Ayaka</au><au>Tsuchiya, Syoutarou</au><au>Kaneko, Yumi</au><au>Sato, Kazufumi</au><au>Ozaki, Tomoya</au><au>Araki, Yasuyuki</au><au>Nishimura, Mitsuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the presence of trophectoderm vesicles on blastocyst in relation to in vitro hatching, clinical pregnancy, and miscarriage rates</atitle><jtitle>Human cell : official journal of Human Cell Research Society</jtitle><stitle>Human Cell</stitle><addtitle>Hum Cell</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>29</volume><issue>4</issue><spage>176</spage><epage>180</epage><pages>176-180</pages><issn>1749-0774</issn><issn>0914-7470</issn><eissn>1749-0774</eissn><abstract>Trophectoderm vesicles (TVs) are observed in some blastocysts that penetrate cells from the zona pellucida to the outer margin. Therefore, we compared this incidence in relation to hatching, pregnancy, and miscarriage rates between conventional in vitro fertilization (c-IVF) and intracytoplasmic sperm injection (ICSI). Vitrified/warmed blastocysts (
n
= 112) were derived from surplus embryos. The blastocysts were then observed using time-lapse cinematography to resolve the relationship between hatching and implantation. Another study was conducted that comprised 681 embryo transfer cycles in 533 patients who received a single vitrified/warmed blastocyst from our clinic. The incidence of TV was significantly higher in embryos inseminated by ICSI compared with c-IVF [ICSI: 51/56 (91 %); c-IVF: 25/56 (45 %);
P
< 0.01]. The successful hatching rate was significantly lower in ICSI than in c-IVF [ICSI: 11/56 (20 %); c-IVF: 29/56 (52 %);
P
< 0.01]. In addition, the hatching rate was significantly lower when TVs were present (14/76; 18 %) than in non-TV embryos (26/36; 72 %) (
P
< 0.01). In regard to the clinical study results, no significant differences were found between the groups in the pregnancy rate (TV present group: 107/183, 58.5 %; TV absent group: 273/498, 54.8 %) and miscarriage rate (TV present group: 21/107, 19.6 %; TV absent group: 53/273, 19.4 %). In vivo, we hypothesized that hatching and hatched would occur naturally by assisting protease action in the uterus; therefore, these results suggest that the presence of TV has no effect on pregnancy rates in the clinical setting.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27277221</pmid><doi>10.1007/s13577-016-0141-y</doi><tpages>5</tpages></addata></record> |
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| subjects | Abortion, Spontaneous Adult Biomedical and Life Sciences Blastocyst - cytology Blastocyst - physiology Blastocysts Cell Biology Cinematography Embryo Implantation Embryo Transfer Female Fertility Fertilization in Vitro Gynecology Hatching Humans Implantation In vitro fertilization Life Sciences Oncology Pregnancy Pregnancy Rate Reproductive Medicine Research Article Sperm Injections, Intracytoplasmic Stem Cells Surgery Trophectoderm Uterus Vesicles Zona Pellucida |
| title | Effect of the presence of trophectoderm vesicles on blastocyst in relation to in vitro hatching, clinical pregnancy, and miscarriage rates |
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