Considerations for Developing a Zika Virus Vaccine

The scientific feasibility of developing a safe, effective Zika vaccine doesn't ensure successful development. An efficient development pathway must be delineated, including better ways to evaluate vaccine candidates for intended target populations. The rapid spread of Zika virus through the Americas and its devastating consequences for pregnant women and infants have precipitated an international, multisectoral response. Current prevention strategies focus on mosquito control, protection of the blood supply, barrier protection during sex, and other forms of contraception. When this explosive epidemic abates, Zika virus could remain endemic in many countries, where the risk to pregnant women, the general public, and travelers will persist. Therefore, a safe and effective vaccine is essential. Development of a safe, effective Zika vaccine should be feasible. Vaccines against related flaviviruses, such as yellow fever and Japanese encephalitis, . . .