Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of β-catenin-mutated mouse liver tumors

Tumor promoters are non-mutagenic chemicals which increase the probability of cancer by accelerating the clonal expansion of cells transformed during tumor initiation. Phenobarbital (PB) is an antiepileptic drug which promotes hepatocarcinogenesis in rodents when administered subsequent to an initia...

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Veröffentlicht in:	Oncogene 2001-11, Vol.20 (53), p.7812-7816
Hauptverfasser:	AYDINLIK, Huriye, NGUYEN, Tri Dung, MOENNIKES, Oliver, BUCHMANN, Albrecht, SCHWARZ, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiepileptic agents b-catenin Base Sequence beta Catenin Biological and medical sciences Carcinogens Carcinogens - pharmacology Cell Division - drug effects Clone Cells - drug effects Clone Cells - metabolism Clone Cells - pathology Cytoskeletal Proteins - analysis Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Diethylnitrosamine Diethylnitrosamine - pharmacology DNA Mutational Analysis DNA, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Genes, ras - genetics Ha-ras gene Hybridization Immunohistochemistry Liver cancer Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Mice Mice, Knockout Molecular and cellular biology Molecular Sequence Data Mutagenesis - drug effects Mutagenesis - genetics Mutation Negative selection Oligonucleotides Phenobarbital Phenobarbital - pharmacology Polymerase Chain Reaction Selection, Genetic Trans-Activators Tumorigenesis Tumors β-Catenin
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