Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

Phosphatidylinositol 3′-kinase (PI3K) and the serine/threonine kinase AKT have critical roles in phosphorylating and transactivating the p65 subunit of nuclear factor κB (NF-κB) in response to the pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF). Mouse embryo fibroblas...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (6), p.3863-3869
Hauptverfasser:	Sizemore, Nywana, Lerner, Natalia, Dombrowski, Nicole, Sakurai, Hiroaki, Stark, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt protein IKK^a protein IKK^b protein
Online-Zugang:	Volltext
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