Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis
The aim of this study was to investigate in vitro the relative impact of ethylene glycol, a major industrial chemical, and its individual metabolites on the embryonic development of rats. Rat whole embryos were exposed for 48 h (day 9.5–11.5 of gestation) to ethylene glycol (EG) and its metabolites...
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| Veröffentlicht in: | Toxicology in vitro 2001-12, Vol.15 (6), p.635-642 |
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| creator | Klug, S Merker, H.-J Jäckh, R |
| description | The aim of this study was to investigate in vitro the relative impact of ethylene glycol, a major industrial chemical, and its individual metabolites on the embryonic development of rats. Rat whole embryos were exposed for 48 h (day 9.5–11.5 of gestation) to ethylene glycol (EG) and its metabolites glycolaldehyde (GAl), glycolic acid (GA), glyoxylic acid (GXA), glyoxale (GXAl) and oxalic acid (OXA) at increasing concentrations. Embryotoxic concentrations were achieved within the following range: ethylene glycol (100–200 m
m), glycolic acid (3 m
m), glyoxal (6 m
m), oxalic acid (1–3 m
m), glyoxylic acid (0.3–1 m
m), glycolaldehyde (0.1–0.2 m
m). The pattern of dysmorphogenesis with all compounds including EG showed a general embryotoxicity with diffusely distributed cell necroses with no specific target tissues selectively affected. The results obtained in this study emphasize the hypothesis that the metabolites and not ethylene glycol itself are responsible for the embryotoxicity of ethylene glycol in rats. |
| doi_str_mv | 10.1016/S0887-2333(01)00083-2 |
| format | Article |
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m), glycolic acid (3 m
m), glyoxal (6 m
m), oxalic acid (1–3 m
m), glyoxylic acid (0.3–1 m
m), glycolaldehyde (0.1–0.2 m
m). The pattern of dysmorphogenesis with all compounds including EG showed a general embryotoxicity with diffusely distributed cell necroses with no specific target tissues selectively affected. The results obtained in this study emphasize the hypothesis that the metabolites and not ethylene glycol itself are responsible for the embryotoxicity of ethylene glycol in rats.</description><identifier>ISSN: 0887-2333</identifier><identifier>EISSN: 1879-3177</identifier><identifier>DOI: 10.1016/S0887-2333(01)00083-2</identifier><identifier>PMID: 11698163</identifier><identifier>CODEN: TIVIEQ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Abnormalities, Drug-Induced - pathology ; Acetaldehyde - analogs & derivatives ; Acetaldehyde - toxicity ; Animal Testing Alternatives ; Animals ; Biological and medical sciences ; Developmental toxicity ; Dose-Response Relationship, Drug ; Embryo, Mammalian - drug effects ; Embryo, Mammalian - pathology ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - drug effects ; Ethylene glycol ; Ethylene Glycol - metabolism ; Ethylene Glycol - toxicity ; Female ; Fundamental and applied biological sciences. Psychology ; Glycolates - toxicity ; Glyoxal - toxicity ; Glyoxylates - toxicity ; In vitro ; Metabolites ; Organ Culture Techniques ; Organogenesis ; Oxalic Acid - toxicity ; Pregnancy ; Rats ; Rats, Wistar ; Specific Pathogen-Free Organisms ; Teratogens - metabolism ; Teratogens - toxicity ; Teratology. Teratogens</subject><ispartof>Toxicology in vitro, 2001-12, Vol.15 (6), p.635-642</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-cbce419e6dc67476e93d05aa0b216c673360df2a34aa2c111848d978c719f253</citedby><cites>FETCH-LOGICAL-c422t-cbce419e6dc67476e93d05aa0b216c673360df2a34aa2c111848d978c719f253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0887-2333(01)00083-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14125983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11698163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klug, S</creatorcontrib><creatorcontrib>Merker, H.-J</creatorcontrib><creatorcontrib>Jäckh, R</creatorcontrib><title>Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis</title><title>Toxicology in vitro</title><addtitle>Toxicol In Vitro</addtitle><description>The aim of this study was to investigate in vitro the relative impact of ethylene glycol, a major industrial chemical, and its individual metabolites on the embryonic development of rats. Rat whole embryos were exposed for 48 h (day 9.5–11.5 of gestation) to ethylene glycol (EG) and its metabolites glycolaldehyde (GAl), glycolic acid (GA), glyoxylic acid (GXA), glyoxale (GXAl) and oxalic acid (OXA) at increasing concentrations. Embryotoxic concentrations were achieved within the following range: ethylene glycol (100–200 m
m), glycolic acid (3 m
m), glyoxal (6 m
m), oxalic acid (1–3 m
m), glyoxylic acid (0.3–1 m
m), glycolaldehyde (0.1–0.2 m
m). The pattern of dysmorphogenesis with all compounds including EG showed a general embryotoxicity with diffusely distributed cell necroses with no specific target tissues selectively affected. The results obtained in this study emphasize the hypothesis that the metabolites and not ethylene glycol itself are responsible for the embryotoxicity of ethylene glycol in rats.</description><subject>Abnormalities, Drug-Induced - pathology</subject><subject>Acetaldehyde - analogs & derivatives</subject><subject>Acetaldehyde - toxicity</subject><subject>Animal Testing Alternatives</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Developmental toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Embryo, Mammalian - drug effects</subject><subject>Embryo, Mammalian - pathology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development - drug effects</subject><subject>Ethylene glycol</subject><subject>Ethylene Glycol - metabolism</subject><subject>Ethylene Glycol - toxicity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycolates - toxicity</subject><subject>Glyoxal - toxicity</subject><subject>Glyoxylates - toxicity</subject><subject>In vitro</subject><subject>Metabolites</subject><subject>Organ Culture Techniques</subject><subject>Organogenesis</subject><subject>Oxalic Acid - toxicity</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Teratogens - metabolism</subject><subject>Teratogens - toxicity</subject><subject>Teratology. Teratogens</subject><issn>0887-2333</issn><issn>1879-3177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEQgC1ERUPgJ4B8AcFhi8feh_dUoapApUoc2rvltWeDkdcOthMp_x6nieiR02hG3zz0DSHvgF0Bg_7LA5NyaLgQ4hODz4wxKRr-gqxADmMjYBhektU_5JK8zvl3hTrJ2StyCdCPEnqxIvPtPKMpmcaZYvl18BiQbvzBRE91sHTBoqfoXcGKBOoC3buSIrW4Rx-3C4ZybE26UFymdIiZ2l1yYUNj2ugQN3VedvkNuZi1z_j2HNfk8dvt482P5v7n97ubr_eNaTkvjZkMtjBib00_tEOPo7Cs05pNHPpaEqJnduZatFpzAwCylXYcpBlgnHkn1uTjaew2xT87zEUtLhv0XgeMu6xA8rYVQlawO4EmxZwTzmqb3KLTQQFTR7_qya86ylMM1JPfmq3J-_OC3bSgfe46C63AhzOgs9F-TjoYl5-5Fng3yiN3feKw2tg7TCobh8Ggdan-Q9no_nPKX0LjmDE</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Klug, S</creator><creator>Merker, H.-J</creator><creator>Jäckh, R</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20011201</creationdate><title>Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis</title><author>Klug, S ; Merker, H.-J ; Jäckh, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-cbce419e6dc67476e93d05aa0b216c673360df2a34aa2c111848d978c719f253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abnormalities, Drug-Induced - pathology</topic><topic>Acetaldehyde - analogs & derivatives</topic><topic>Acetaldehyde - toxicity</topic><topic>Animal Testing Alternatives</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Developmental toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Embryo, Mammalian - drug effects</topic><topic>Embryo, Mammalian - pathology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development - drug effects</topic><topic>Ethylene glycol</topic><topic>Ethylene Glycol - metabolism</topic><topic>Ethylene Glycol - toxicity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycolates - toxicity</topic><topic>Glyoxal - toxicity</topic><topic>Glyoxylates - toxicity</topic><topic>In vitro</topic><topic>Metabolites</topic><topic>Organ Culture Techniques</topic><topic>Organogenesis</topic><topic>Oxalic Acid - toxicity</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Teratogens - metabolism</topic><topic>Teratogens - toxicity</topic><topic>Teratology. Teratogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klug, S</creatorcontrib><creatorcontrib>Merker, H.-J</creatorcontrib><creatorcontrib>Jäckh, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology in vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klug, S</au><au>Merker, H.-J</au><au>Jäckh, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis</atitle><jtitle>Toxicology in vitro</jtitle><addtitle>Toxicol In Vitro</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>15</volume><issue>6</issue><spage>635</spage><epage>642</epage><pages>635-642</pages><issn>0887-2333</issn><eissn>1879-3177</eissn><coden>TIVIEQ</coden><abstract>The aim of this study was to investigate in vitro the relative impact of ethylene glycol, a major industrial chemical, and its individual metabolites on the embryonic development of rats. Rat whole embryos were exposed for 48 h (day 9.5–11.5 of gestation) to ethylene glycol (EG) and its metabolites glycolaldehyde (GAl), glycolic acid (GA), glyoxylic acid (GXA), glyoxale (GXAl) and oxalic acid (OXA) at increasing concentrations. Embryotoxic concentrations were achieved within the following range: ethylene glycol (100–200 m
m), glycolic acid (3 m
m), glyoxal (6 m
m), oxalic acid (1–3 m
m), glyoxylic acid (0.3–1 m
m), glycolaldehyde (0.1–0.2 m
m). The pattern of dysmorphogenesis with all compounds including EG showed a general embryotoxicity with diffusely distributed cell necroses with no specific target tissues selectively affected. The results obtained in this study emphasize the hypothesis that the metabolites and not ethylene glycol itself are responsible for the embryotoxicity of ethylene glycol in rats.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11698163</pmid><doi>10.1016/S0887-2333(01)00083-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Abnormalities, Drug-Induced - pathology Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Animal Testing Alternatives Animals Biological and medical sciences Developmental toxicity Dose-Response Relationship, Drug Embryo, Mammalian - drug effects Embryo, Mammalian - pathology Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Ethylene glycol Ethylene Glycol - metabolism Ethylene Glycol - toxicity Female Fundamental and applied biological sciences. Psychology Glycolates - toxicity Glyoxal - toxicity Glyoxylates - toxicity In vitro Metabolites Organ Culture Techniques Organogenesis Oxalic Acid - toxicity Pregnancy Rats Rats, Wistar Specific Pathogen-Free Organisms Teratogens - metabolism Teratogens - toxicity Teratology. Teratogens |
| title | Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis |
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