Metabolic syndrome is associated with disease activity in patients with rheumatoid arthritis
Abstract Objective To investigate the association between metabolic syndrome (MS) and disease activity in patients with rheumatoid arthritis (RA). Methods Siriraj Rheumatoid Arthritis registry is a prospective cohort study establishing since May 2011. A total of 267 patients who had complete data in...
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Veröffentlicht in: | Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2016-10, Vol.83 (5), p.563-567 |
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creator | Tantayakom, Pongchirat Koolvisoot, Ajchara Arromdee, Emvalee Chiowchanwisawakit, Praveena Muangchan, Chayawee Katchamart, Wanruchada |
description | Abstract Objective To investigate the association between metabolic syndrome (MS) and disease activity in patients with rheumatoid arthritis (RA). Methods Siriraj Rheumatoid Arthritis registry is a prospective cohort study establishing since May 2011. A total of 267 patients who had complete data in February 2015 were included in these analyses. All clinical and laboratory data related to disease activity, functional status, and parameters of MS according to the 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) were collected. Univariate and backward stepwise multivariate analyses were performed to identify factors associated with MS. Results Most (88%) were female with the mean age ± standard deviation of 59 ± 11.1 years old. MS was found in 43 patients (16%). Patients with MS had a significantly lower proportion of patients with remission (time-adjusted mean of disease activity score 28 or DAS28 < 2.6) than those with non-MS (2.3% vs. 16.5%, P = 0.02). Multiple logistic regression analysis identified 3 independent factors associated with MS including body mass index [OR 1.2, 95% CI 1.1 to 1.3], educational level ≤ 12 years [OR 5.92, 95% CI 1.47 to 23.83], and disease remission [OR 0.11, 95% CI 0.01 to 0.93]. This model correctly predicted 84% of cases. Conclusion Remission rate is significantly lower in RA patients with MS. Disease activity of RA, body mass index, and educational level are associated with metabolic syndrome in patients with RA. |
doi_str_mv | 10.1016/j.jbspin.2015.10.016 |
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Methods Siriraj Rheumatoid Arthritis registry is a prospective cohort study establishing since May 2011. A total of 267 patients who had complete data in February 2015 were included in these analyses. All clinical and laboratory data related to disease activity, functional status, and parameters of MS according to the 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) were collected. Univariate and backward stepwise multivariate analyses were performed to identify factors associated with MS. Results Most (88%) were female with the mean age ± standard deviation of 59 ± 11.1 years old. MS was found in 43 patients (16%). Patients with MS had a significantly lower proportion of patients with remission (time-adjusted mean of disease activity score 28 or DAS28 < 2.6) than those with non-MS (2.3% vs. 16.5%, P = 0.02). Multiple logistic regression analysis identified 3 independent factors associated with MS including body mass index [OR 1.2, 95% CI 1.1 to 1.3], educational level ≤ 12 years [OR 5.92, 95% CI 1.47 to 23.83], and disease remission [OR 0.11, 95% CI 0.01 to 0.93]. This model correctly predicted 84% of cases. Conclusion Remission rate is significantly lower in RA patients with MS. Disease activity of RA, body mass index, and educational level are associated with metabolic syndrome in patients with RA.</description><identifier>ISSN: 1297-319X</identifier><identifier>EISSN: 1778-7254</identifier><identifier>DOI: 10.1016/j.jbspin.2015.10.016</identifier><identifier>PMID: 27238198</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>Aged ; Arthritis, Rheumatoid - epidemiology ; Arthritis, Rheumatoid - physiopathology ; Cardiovascular Diseases - epidemiology ; DAS28 ; Disease activity ; Disease Progression ; Female ; Humans ; Internal Medicine ; Male ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - physiopathology ; Middle Aged ; Prevalence ; Prospective Studies ; Registries ; Remission Induction ; Rheumatoid arthritis ; Rheumatology ; Risk Factors ; Severity of Illness Index</subject><ispartof>Joint, bone, spine : revue du rhumatisme, 2016-10, Vol.83 (5), p.563-567</ispartof><rights>Société française de rhumatologie</rights><rights>2016 Société française de rhumatologie</rights><rights>Copyright © 2016 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-22e7a7353382bf4e1152118bbece765b7d528894ed34c52162743de3def2fac3</citedby><cites>FETCH-LOGICAL-c417t-22e7a7353382bf4e1152118bbece765b7d528894ed34c52162743de3def2fac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbspin.2015.10.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27238198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tantayakom, Pongchirat</creatorcontrib><creatorcontrib>Koolvisoot, Ajchara</creatorcontrib><creatorcontrib>Arromdee, Emvalee</creatorcontrib><creatorcontrib>Chiowchanwisawakit, Praveena</creatorcontrib><creatorcontrib>Muangchan, Chayawee</creatorcontrib><creatorcontrib>Katchamart, Wanruchada</creatorcontrib><title>Metabolic syndrome is associated with disease activity in patients with rheumatoid arthritis</title><title>Joint, bone, spine : revue du rhumatisme</title><addtitle>Joint Bone Spine</addtitle><description>Abstract Objective To investigate the association between metabolic syndrome (MS) and disease activity in patients with rheumatoid arthritis (RA). Methods Siriraj Rheumatoid Arthritis registry is a prospective cohort study establishing since May 2011. A total of 267 patients who had complete data in February 2015 were included in these analyses. All clinical and laboratory data related to disease activity, functional status, and parameters of MS according to the 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) were collected. Univariate and backward stepwise multivariate analyses were performed to identify factors associated with MS. Results Most (88%) were female with the mean age ± standard deviation of 59 ± 11.1 years old. MS was found in 43 patients (16%). Patients with MS had a significantly lower proportion of patients with remission (time-adjusted mean of disease activity score 28 or DAS28 < 2.6) than those with non-MS (2.3% vs. 16.5%, P = 0.02). Multiple logistic regression analysis identified 3 independent factors associated with MS including body mass index [OR 1.2, 95% CI 1.1 to 1.3], educational level ≤ 12 years [OR 5.92, 95% CI 1.47 to 23.83], and disease remission [OR 0.11, 95% CI 0.01 to 0.93]. This model correctly predicted 84% of cases. Conclusion Remission rate is significantly lower in RA patients with MS. Disease activity of RA, body mass index, and educational level are associated with metabolic syndrome in patients with RA.</description><subject>Aged</subject><subject>Arthritis, Rheumatoid - epidemiology</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>DAS28</subject><subject>Disease activity</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Remission Induction</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>1297-319X</issn><issn>1778-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVpadK036AUHXvx1pJsy3splJD-gZQekkMOASFLY3Zc29pq5JT99pFx2kMvBYHE05sZ5vcYeyvKnShF82HYDR0dcd7JUtRZ2mXxGTsXWreFlnX1PL_lXhdK7O_O2CuioSxLJevmJTuTWqpW7Ntzdv8dku3CiI7TafYxTMCRuCUKDm0Cz39jOnCPBJaAW5fwAdOJ48yPNiHMiTZHPMAy2RTQcxvTIWJCes1e9HYkePN0X7Dbz1e3l1-L6x9fvl1-ui5cJXQqpARttaqVamXXVyBELYVouw4c6KbutK9l2-4r8Kpy-auRulIe8ullb526YO-3tscYfi1AyUxIDsbRzhAWMqKVlZRKNXW2VpvVxUAUoTfHiJONJyNKs2I1g9mwmhXrqmYxl717mrB0E_i_RX84ZsPHzQB5zQeEaMhlOA48RnDJ-ID_m_BvAzfijM6OP-EENIQlzhmhEYakKc3NGu2arGhyqpXU6hE5qqFZ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Tantayakom, Pongchirat</creator><creator>Koolvisoot, Ajchara</creator><creator>Arromdee, Emvalee</creator><creator>Chiowchanwisawakit, Praveena</creator><creator>Muangchan, Chayawee</creator><creator>Katchamart, Wanruchada</creator><general>Elsevier SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161001</creationdate><title>Metabolic syndrome is associated with disease activity in patients with rheumatoid arthritis</title><author>Tantayakom, Pongchirat ; Koolvisoot, Ajchara ; Arromdee, Emvalee ; Chiowchanwisawakit, Praveena ; Muangchan, Chayawee ; Katchamart, Wanruchada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-22e7a7353382bf4e1152118bbece765b7d528894ed34c52162743de3def2fac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Arthritis, Rheumatoid - epidemiology</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>DAS28</topic><topic>Disease activity</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Remission Induction</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tantayakom, Pongchirat</creatorcontrib><creatorcontrib>Koolvisoot, Ajchara</creatorcontrib><creatorcontrib>Arromdee, Emvalee</creatorcontrib><creatorcontrib>Chiowchanwisawakit, Praveena</creatorcontrib><creatorcontrib>Muangchan, Chayawee</creatorcontrib><creatorcontrib>Katchamart, Wanruchada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tantayakom, Pongchirat</au><au>Koolvisoot, Ajchara</au><au>Arromdee, Emvalee</au><au>Chiowchanwisawakit, Praveena</au><au>Muangchan, Chayawee</au><au>Katchamart, Wanruchada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome is associated with disease activity in patients with rheumatoid arthritis</atitle><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle><addtitle>Joint Bone Spine</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>83</volume><issue>5</issue><spage>563</spage><epage>567</epage><pages>563-567</pages><issn>1297-319X</issn><eissn>1778-7254</eissn><abstract>Abstract Objective To investigate the association between metabolic syndrome (MS) and disease activity in patients with rheumatoid arthritis (RA). Methods Siriraj Rheumatoid Arthritis registry is a prospective cohort study establishing since May 2011. A total of 267 patients who had complete data in February 2015 were included in these analyses. All clinical and laboratory data related to disease activity, functional status, and parameters of MS according to the 2001 National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) were collected. Univariate and backward stepwise multivariate analyses were performed to identify factors associated with MS. Results Most (88%) were female with the mean age ± standard deviation of 59 ± 11.1 years old. MS was found in 43 patients (16%). Patients with MS had a significantly lower proportion of patients with remission (time-adjusted mean of disease activity score 28 or DAS28 < 2.6) than those with non-MS (2.3% vs. 16.5%, P = 0.02). Multiple logistic regression analysis identified 3 independent factors associated with MS including body mass index [OR 1.2, 95% CI 1.1 to 1.3], educational level ≤ 12 years [OR 5.92, 95% CI 1.47 to 23.83], and disease remission [OR 0.11, 95% CI 0.01 to 0.93]. This model correctly predicted 84% of cases. Conclusion Remission rate is significantly lower in RA patients with MS. Disease activity of RA, body mass index, and educational level are associated with metabolic syndrome in patients with RA.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>27238198</pmid><doi>10.1016/j.jbspin.2015.10.016</doi><tpages>5</tpages></addata></record> |
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subjects | Aged Arthritis, Rheumatoid - epidemiology Arthritis, Rheumatoid - physiopathology Cardiovascular Diseases - epidemiology DAS28 Disease activity Disease Progression Female Humans Internal Medicine Male Metabolic syndrome Metabolic Syndrome - epidemiology Metabolic Syndrome - physiopathology Middle Aged Prevalence Prospective Studies Registries Remission Induction Rheumatoid arthritis Rheumatology Risk Factors Severity of Illness Index |
title | Metabolic syndrome is associated with disease activity in patients with rheumatoid arthritis |
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