Comparative proteomic analysis of colon cancer cells in response to Oxaliplatin treatment

Colon cancer is one of the most common malignancies in the world. Oxaliplatin, a third-generation platinum compound, is widely used in clinical chemotherapy of colon cancer. Although the mechanisms of the antitumor effect of Oxaliplatin have been investigated in recent years, the proteomic changes t...

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Veröffentlicht in:	Biochimica et biophysica acta 2009-10, Vol.1794 (10), p.1433-1440
Hauptverfasser:	Yao, Yi, Jia, Xiao-Yuan, Tian, Hong-Yu, Jiang, Yu-Xiang, Xu, Gen-Jun, Qian, Qi-Jun, Zhao, Fu-Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	2-DE Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Electrophoresis, Gel, Two-Dimensional Humans Immunoblotting Mass spectrometry Neoplasm Proteins - isolation & purification Neoplasm Proteins - metabolism Organoplatinum Compounds - therapeutic use Oxaliplatin Proteome - drug effects Proteome - isolation & purification Proteome - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tandem Mass Spectrometry
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