Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men
Endogenous testosterone is known to be protective against metabolic syndrome (MetS) in men. While various markers of testosterone status including serum total testosterone (TT), free testosterone (measured using analogue ligand RIA [aFT]), calculated FT (cFT), calculated bioavailable testosterone (c...
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| Veröffentlicht in: | ENDOCRINE JOURNAL 2015, Vol.62(2), pp.123-132 |
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| creator | Tanabe, Makito Akehi, Yuko Nomiyama, Takashi Murakami, Junji Yanase, Toshihiko |
| description | Endogenous testosterone is known to be protective against metabolic syndrome (MetS) in men. While various markers of testosterone status including serum total testosterone (TT), free testosterone (measured using analogue ligand RIA [aFT]), calculated FT (cFT), calculated bioavailable testosterone (cbT), and sex-hormone binding globulin (SHBG) are recognized, it is unclear which of these markers are the most appropriate ones for the detection of MetS. We measured various testosterone values and metabolic markers in 249 healthy Japanese males (mean age 52.7 ± 7.4 yr) and analyzed which testosterone value is most associated with various metabolic parameters, including MetS as diagnosed according to the International Diabetes Federation (IDF, 2009 version) or with the Japanese criteria. Age had no effect on the TT level but significantly decreased aFT, cFT, and cbT levels and significantly increased the SHBG level. All testosterone values and SHBG showed weak inverse relationships with the metabolic markers BMI, waist circumference, insulin, HOMA-R, and HOMA-β, with the strongest relationship being to TT. TT and SHBG were significantly lower in men with MetS than in men without MetS. All testosterone values gradually decreased as the number of MetS components increased. Multivariate analysis revealed that the TT median value of |
| doi_str_mv | 10.1507/endocrj.EJ14-0313 |
| format | Article |
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While various markers of testosterone status including serum total testosterone (TT), free testosterone (measured using analogue ligand RIA [aFT]), calculated FT (cFT), calculated bioavailable testosterone (cbT), and sex-hormone binding globulin (SHBG) are recognized, it is unclear which of these markers are the most appropriate ones for the detection of MetS. We measured various testosterone values and metabolic markers in 249 healthy Japanese males (mean age 52.7 ± 7.4 yr) and analyzed which testosterone value is most associated with various metabolic parameters, including MetS as diagnosed according to the International Diabetes Federation (IDF, 2009 version) or with the Japanese criteria. Age had no effect on the TT level but significantly decreased aFT, cFT, and cbT levels and significantly increased the SHBG level. All testosterone values and SHBG showed weak inverse relationships with the metabolic markers BMI, waist circumference, insulin, HOMA-R, and HOMA-β, with the strongest relationship being to TT. TT and SHBG were significantly lower in men with MetS than in men without MetS. All testosterone values gradually decreased as the number of MetS components increased. Multivariate analysis revealed that the TT median value of <4.0 ng/mL was the only significant marker for the detection of MetS. These results were essentially the same regardless of whether the diagnosis of MetS was based on the IDF or the Japanese criteria. In conclusion, among various testosterone values, TT is the most reliable indicator of MetS in middle-aged Japanese men.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ14-0313</identifier><identifier>PMID: 25342164</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Aging ; Biomarkers - blood ; Body Mass Index ; Down-Regulation ; Early Diagnosis ; Humans ; Hypogonadism - etiology ; Immunoassay ; Insulin - blood ; Insulin Resistance ; Japan - epidemiology ; Late onset hypogonadism ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - diagnosis ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - physiopathology ; Middle Aged ; Reproducibility of Results ; Risk Factors ; Sex Hormone-Binding Globulin - analysis ; Testosterone ; Testosterone - blood ; Waist Circumference</subject><ispartof>Endocrine Journal, 2015, Vol.62(2), pp.123-132</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c696t-9c46d9179991022760e0f3481b64c47837c97440a38562d25c8fb9b0ea7de47c3</citedby><cites>FETCH-LOGICAL-c696t-9c46d9179991022760e0f3481b64c47837c97440a38562d25c8fb9b0ea7de47c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25342164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanabe, Makito</creatorcontrib><creatorcontrib>Akehi, Yuko</creatorcontrib><creatorcontrib>Nomiyama, Takashi</creatorcontrib><creatorcontrib>Murakami, Junji</creatorcontrib><creatorcontrib>Yanase, Toshihiko</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>Department of Endocrinology and Diabetes Mellitus</creatorcontrib><creatorcontrib>Iizuka Hospital</creatorcontrib><creatorcontrib>Department of Preventive Medicine</creatorcontrib><title>Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>Endogenous testosterone is known to be protective against metabolic syndrome (MetS) in men. While various markers of testosterone status including serum total testosterone (TT), free testosterone (measured using analogue ligand RIA [aFT]), calculated FT (cFT), calculated bioavailable testosterone (cbT), and sex-hormone binding globulin (SHBG) are recognized, it is unclear which of these markers are the most appropriate ones for the detection of MetS. We measured various testosterone values and metabolic markers in 249 healthy Japanese males (mean age 52.7 ± 7.4 yr) and analyzed which testosterone value is most associated with various metabolic parameters, including MetS as diagnosed according to the International Diabetes Federation (IDF, 2009 version) or with the Japanese criteria. Age had no effect on the TT level but significantly decreased aFT, cFT, and cbT levels and significantly increased the SHBG level. All testosterone values and SHBG showed weak inverse relationships with the metabolic markers BMI, waist circumference, insulin, HOMA-R, and HOMA-β, with the strongest relationship being to TT. TT and SHBG were significantly lower in men with MetS than in men without MetS. All testosterone values gradually decreased as the number of MetS components increased. Multivariate analysis revealed that the TT median value of <4.0 ng/mL was the only significant marker for the detection of MetS. These results were essentially the same regardless of whether the diagnosis of MetS was based on the IDF or the Japanese criteria. In conclusion, among various testosterone values, TT is the most reliable indicator of MetS in middle-aged Japanese men.</description><subject>Aging</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Down-Regulation</subject><subject>Early Diagnosis</subject><subject>Humans</subject><subject>Hypogonadism - etiology</subject><subject>Immunoassay</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Japan - epidemiology</subject><subject>Late onset hypogonadism</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - diagnosis</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Waist Circumference</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCIbhd-ABfkI5cUf8WJj6gqpVUlLuVsOc6kzcqJt7YXqT-g_5sJuwRx4uCxNH7z5vk9Qj5wdsFr1nyGuY8-7S6ubrmqmOTyFdlwqdpK1Yq9JhtmeFu1pjZn5DznHWNS1kq-JWeilkpwrTbk5T4WF2iBXGIukOIMdMy0PAKdsEF_unBwXcDm3I_elZhoHOgExXUxjJ7m57lPcQLqpjg_IDyN8ZD_5Vs4ICMDnca-D1C5B-jprdu7GTLugfkdeTO4kOH96d6SH1-v7i-_VXffr28uv9xVXhtdKuOV7g1vjDGcCdFoBmzA__JOK6-aVjbeNEoxJ9tai17Uvh060zFwTQ-q8XJLPh159yk-oaZipzF7CAGVoGzLWyGN4mjb_6Fai5OhW8KPUJ9izgkGu0_j5NKz5cwuQdlTUHYJyi5B4czHE_2hm6BfJ_4kg4DrIwBf0fgQ5zDOYHfxkGa0yPon_ZvVCsZryxiqEXjh4UJikUIozoyu_zLtckHn11UuldEHWMVpYcVSVpErwj-6hDD5Cx8rwdA</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Tanabe, Makito</creator><creator>Akehi, Yuko</creator><creator>Nomiyama, Takashi</creator><creator>Murakami, Junji</creator><creator>Yanase, Toshihiko</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2015</creationdate><title>Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men</title><author>Tanabe, Makito ; Akehi, Yuko ; Nomiyama, Takashi ; Murakami, Junji ; Yanase, Toshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c696t-9c46d9179991022760e0f3481b64c47837c97440a38562d25c8fb9b0ea7de47c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aging</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Down-Regulation</topic><topic>Early Diagnosis</topic><topic>Humans</topic><topic>Hypogonadism - etiology</topic><topic>Immunoassay</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Japan - epidemiology</topic><topic>Late onset hypogonadism</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - diagnosis</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Makito</creatorcontrib><creatorcontrib>Akehi, Yuko</creatorcontrib><creatorcontrib>Nomiyama, Takashi</creatorcontrib><creatorcontrib>Murakami, Junji</creatorcontrib><creatorcontrib>Yanase, Toshihiko</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>Department of Endocrinology and Diabetes Mellitus</creatorcontrib><creatorcontrib>Iizuka Hospital</creatorcontrib><creatorcontrib>Department of Preventive Medicine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Makito</au><au>Akehi, Yuko</au><au>Nomiyama, Takashi</au><au>Murakami, Junji</au><au>Yanase, Toshihiko</au><aucorp>Faculty of Medicine</aucorp><aucorp>Fukuoka University</aucorp><aucorp>Department of Endocrinology and Diabetes Mellitus</aucorp><aucorp>Iizuka Hospital</aucorp><aucorp>Department of Preventive Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2015</date><risdate>2015</risdate><volume>62</volume><issue>2</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Endogenous testosterone is known to be protective against metabolic syndrome (MetS) in men. While various markers of testosterone status including serum total testosterone (TT), free testosterone (measured using analogue ligand RIA [aFT]), calculated FT (cFT), calculated bioavailable testosterone (cbT), and sex-hormone binding globulin (SHBG) are recognized, it is unclear which of these markers are the most appropriate ones for the detection of MetS. We measured various testosterone values and metabolic markers in 249 healthy Japanese males (mean age 52.7 ± 7.4 yr) and analyzed which testosterone value is most associated with various metabolic parameters, including MetS as diagnosed according to the International Diabetes Federation (IDF, 2009 version) or with the Japanese criteria. Age had no effect on the TT level but significantly decreased aFT, cFT, and cbT levels and significantly increased the SHBG level. All testosterone values and SHBG showed weak inverse relationships with the metabolic markers BMI, waist circumference, insulin, HOMA-R, and HOMA-β, with the strongest relationship being to TT. TT and SHBG were significantly lower in men with MetS than in men without MetS. All testosterone values gradually decreased as the number of MetS components increased. Multivariate analysis revealed that the TT median value of <4.0 ng/mL was the only significant marker for the detection of MetS. These results were essentially the same regardless of whether the diagnosis of MetS was based on the IDF or the Japanese criteria. In conclusion, among various testosterone values, TT is the most reliable indicator of MetS in middle-aged Japanese men.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>25342164</pmid><doi>10.1507/endocrj.EJ14-0313</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging Biomarkers - blood Body Mass Index Down-Regulation Early Diagnosis Humans Hypogonadism - etiology Immunoassay Insulin - blood Insulin Resistance Japan - epidemiology Late onset hypogonadism Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - diagnosis Metabolic Syndrome - epidemiology Metabolic Syndrome - physiopathology Middle Aged Reproducibility of Results Risk Factors Sex Hormone-Binding Globulin - analysis Testosterone Testosterone - blood Waist Circumference |
| title | Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men |
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