New insights into the roles of CHOP-induced apoptosis in ER stress
Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2014-08, Vol.46 (8), p.629-640 |
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| container_title | Acta biochimica et biophysica Sinica |
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| creator | Li, Yiming Guo, Yunshan Tang, Juan Jiang, Jianli Chen, Zhinan |
| description | Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the transcription factor C/EBP hom- ologous protein （CHOP）. Although it has been proved that excessive or adverse stress to the ER triggers apoptosis, the specific mechanisms underlying these processes induced by CHOP remain unclear. By now, CHOP-induced apoptosis in ER stress has been implicated in numerous human dis- eases, such as neurodegenerative diseases, diabetes, ische- mic diseases, tumor, and so on. In this review, we summarized the current understanding of the roles of CHOP in the development of several diseases from the laboratory to the clinic. |
| doi_str_mv | 10.1093/abbs/gmu048 |
| format | Article |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Apoptosis - physiology EBP Endoplasmic Reticulum - metabolism Gene Expression Profiling Humans Stress, Physiological Transcription Factor CHOP - genetics Transcription Factor CHOP - physiology Transcription, Genetic 内质网应激 神经变性疾病 细胞凋亡 自适应机制 蛋白质 诱导剂 转录因子 |
| title | New insights into the roles of CHOP-induced apoptosis in ER stress |
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