Effect of new berberine derivatives on colon cancer cells
The natural alkaloid berberine has been recently described as a promising antlcancer arug. In oraer to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine deriva- tives...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2015-10, Vol.47 (10), p.824-833 |
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| container_title | Acta biochimica et biophysica Sinica |
| container_volume | 47 |
| creator | Guamán Ortiz, Luis Miguel Croce, Anna Leta Aredia, Francesca Sapienza, Simone Fiorillo, Gaetano Syeda, Tanjia Monir Buzzetti, Franco Lombardi, Paolo Scovassi, Anna Ivana |
| description | The natural alkaloid berberine has been recently described as a promising antlcancer arug. In oraer to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine deriva- tives we have produced, five compounds were identified to be able to heavily affect the proliferation of human HCT116 and SW613-B3 colon carcinoma cell lines. Remarkably, these active compounds exhibit high fluorescence emission property and ability to induce autophagy. |
| doi_str_mv | 10.1093/abbs/gmv077 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemical synthesis Apoptosis - drug effects Berberine - administration & dosage Berberine - analogs & derivatives Cell Line, Tumor Cell Proliferation - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Dose-Response Relationship, Drug Drug Design Humans Treatment Outcome 发射特性 小檗碱 活性化合物 生物利用度 癌细胞 结肠癌 衍生物 铅化合物 |
| title | Effect of new berberine derivatives on colon cancer cells |
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